Skip to Main Content





Classical Hodgkin lymphoma is derived by malignant transformation of a mature B cell at the germinal center stage of differentiation and is characterized pathologically by multinucleated Hodgkin and Reed-Sternberg cells embedded in a mixed infiltrate of nonneoplastic cells*. Hodgkin and Reed-Sternberg cells contain monoclonal immunoglobulin gene rearrangements, but have lost most of the B-cell–specific expression program. Multiple signaling pathways and transcription factors are deregulated in Hodgkin lymphoma and genetic lesions involving the JAK-STAT and nuclear factor-κB pathways are commonly identified. Epstein-Barr virus is an important environmental factor in the pathogenesis of Hodgkin lymphoma, and also leads to activation of the nuclear factor-κB pathway. The inflammatory microenvironment promotes survival and allows escape of Hodgkin and Reed-Sternberg cells from immune attack. Morphologic and immunophenotypic features distinguish the four subtypes of classical Hodgkin lymphoma (accounting for 95 percent of cases) from nodular lymphocyte predominance Hodgkin lymphoma (accounting for 5 percent of cases). Hodgkin lymphoma spreads in a predictable, contiguous manner and is classified into four stages, I to IV. Hodgkin lymphoma is treated with the intent to cure the disease in all stages, and long-term survival exceeds 85 percent. Doxorubicin-containing chemotherapy plays a major role in treatment of all stages of the disease whereas radiotherapy is used selectively because of concerns for late toxicities. 18-Fluorodeoxyglucose positron emission tomography is a valuable diagnostic test for assessment of disease extent and response to treatment. High-dose therapy and autologous transplantation are effective in patients who have relapsed, and several promising new biologic agents are available, including brentuximab vedotin (an anti-CD30 antibody–drug conjugate) and nivolumab (an anti-PD1 blocking antibody). Concerns regarding late treatment effects guide therapy and followup decisions in Hodgkin lymphoma, which disproportionately affects adolescents and young adults. Major treatment challenges include the maintenance of high cure rates with fewer short-term and long-term complications, biomarker identification of the small refractory subgroup, and integration of biologic therapies into treatment paradigms.


Acronyms and Abbreviations

ABVD, Adriamycin (doxorubicin), bleomycin, vinblastine, dacarbazine; AP1, activator protein 1; BCMA, B-cell maturation antigen; BEACOPP, bleomycin, etoposide, Adriamycin (doxorubicin), cyclophosphamide, vincristine, procarbazine, prednisone; BEAM, bischloroethylnitrosourea (carmustine), etoposide, Ara C (cytarabine), melphalan; CBV, cyclophosphamide, bischloroethylnitrosourea (carmustine), etoposide; cHL, classical Hodgkin lymphoma; COPP, cyclophosphamide, vincristine, procarbazine, prednisone; CT, computed tomography; DHAP, dexamethasone, cytarabine, cisplatin; EBV, Epstein-Barr virus; EBVP, epirubicin, bleomycin, vinblastine, prednisone; EORTC, European Organization for the Research and Treatment of Cancer; ERK, extracellular signal-regulated kinase; ESR, erythrocyte sedimentation rate; FDG, 18-fluorodeoxyglucose; FIL, Fondazione Italiana Linfomi; GELA, Groupe d'Etude des Lymphomes de l'Adulte; GHSG, German Hodgkin Study Group; GVD, gemcitabine, vinorelbine, liposomal doxorubicin; HLA, human leukocyte antigen; ICE, ifosfamide, carboplatin, etoposide; IL, interleukin; JAK, Janus kinase; LMP, latent membrane protein; LySA, Lymphoma Study Association; MOPP, mechlorethamine (nitrogen mustard), Oncovin (vincristine), procarbazine, prednisone; NF-κB, nuclear factor-κB; NLPHL, nodular lymphocyte-predominant Hodgkin lymphoma; OS, overall survival; PD1, cell death protein 1; PET, positron emission tomography; PI3K, phosphoinositide 3′-kinase; RANK, receptor activator of nuclear factor-κB; R-CHOP, ...

Want remote access to your institution's subscription?

Sign in to your MyAccess profile while you are actively authenticated on this site via your institution (you will be able to verify this by looking at the top right corner of the screen - if you see your institution's name, you are authenticated). Once logged in to your MyAccess profile, you will be able to access your institution's subscription for 90 days from any location. You must be logged in while authenticated at least once every 90 days to maintain this remote access.


About MyAccess

If your institution subscribes to this resource, and you don't have a MyAccess profile, please contact your library's reference desk for information on how to gain access to this resource from off-campus.

Pop-up div Successfully Displayed

This div only appears when the trigger link is hovered over. Otherwise it is hidden from view.