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II.C.001 Alder-Reilly Anomaly

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Graphic Jump Location

II.C.001

Alder-Reilly Anomaly. Blood film. Neutrophil with dense granules simulating toxic granulation. This abnormality of granular content in neutrophils is seen in the mucopolysaccharidoses.

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II.C.002 Alder-Reilly Anomaly

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Graphic Jump Location

II.C.002

Alder-Reilly Anomaly. Blood film. Neutrophil with dense granules simulating toxic granulation. This abnormality of granular content in neutrophils is seen in the mucopolysaccharidoses.

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II.C.003 Chediak-Higashi disease

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Graphic Jump Location

II.C.003

Chediak-Higashi disease. Blood film. Giant granule in neutrophil (arrow). Such neutrophilic granules are key diagnostic characteristics of the disease. Note also, larger than normal granules in the three other leukocytes in the field.

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II.C.004 Chediak-Higashi disease

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Graphic Jump Location

II.C.004

Chediak-Higashi disease. Blood film. Giant granules in neutrophil. These neutrophilic large granules are a diagnostic characteristic of the disease.

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II.C.005 Chediak-Higashi Disease

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Graphic Jump Location

II.C.005

Chediak-Higashi Disease. Blood film showing variable sized abnormal granules in the cytoplasm of neutrophils. Note varying sized abnormal granules from giant-sized to large granules. These abnormal granules are characteristic morphologic findings in cells in this autosomal recessive disorder.

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II.C.006 Colchicine Poisoning

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Graphic Jump Location

II.C.006

Colchicine Poisoning. Blood film. Abnormal neutrophil nuclear configurations. Decreased segmentation.

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II.C.007 Döhle Bodies

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Graphic Jump Location

II.C.007

Döhle bodies. Blood film. Large bluish granules in the cytoplasm of neutrophils as a reflection of inflammatory state. These inclusions are thought to represent basophilic material carried over from the promyelocyte stage, normally degraded, as a result of accelerated maturation of neutrophil precursors during inflammatory states

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II.C.008 Hurler Disease

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Graphic Jump Location

II.C.008

Hurler disease. Neutrophil. Blood film. Note numerous cytoplasmic granules characteristic of this mucopolysaccharidosis. Presumably these are lysosomal accumulations of glycosaminoglycans, characteristic of a deficiency in enzymes that degrade glycosaminoglycan (α-L-iduronidase in Hurler disease).

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II.C.009 Hurler Disease

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Graphic Jump Location

II.C.009

Hurler disease. Neutrophil. Blood film. Note numerous cytoplasmic granules characteristic of this mucopolysaccharidosis. Presumably these are lysosomal accumulations of glycosaminoglycans, characteristic of a deficiency in enzymes that degrade glycosaminoglycan (α-L-iduronidase in Hurler disease).

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II.C.010 Leukocyte Adhesion Deficiency-1

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