Skip to Main Content

++

V.B.001 Increased Iron Aggregates

++
Graphic Jump Location

V.B.001

Increased iron aggregates. Marrow. Prussian blue stain. Several macrophages engorged with iron are noted. The frequency of iron aggregates is greater than seen in normal marrow. Marrow iron is contained in two proteins: hemosiderin and ferritin. Prussian blue stains hemosiderin iron and macrophage iron is principally hemosiderin. In iron deficient states, loss of marrow storage iron in hemosiderin and ferritin is proportionately similar and thus staining for hemosiderin is a reasonable measure of storage iron.

++

V.B.002 Increased Iron Aggregates

++
Graphic Jump Location

V.B.002

Increased iron aggregates. Marrow. Prussian blue stain. The frequency of iron aggregates is greater than seen in normal marrow. Marrow iron is contained in two proteins: hemosiderin and ferritin. Prussian blue stains hemosiderin iron and macrophage iron is principally hemosiderin. In iron deficient states, loss of marrow storage iron in hemosiderin and ferritin is proportionately similar and thus staining for hemosiderin is a reasonable measure of storage iron.

++

V.B.003 Marrow Iron, Unstained

++
Graphic Jump Location

V.B.003

The presence of marrow iron can be determined in unstained marrow samples by the golden brown refractile appearance of hemosiderin aggregates. This is demonstrated in this image of an unstained film of the mixed-fat layer removed from a centrifuged marrow aspirate. Note the increased iron (frequent hemosiderin aggregates) evident in this sample.

++

V.B.004 Marrow Iron

++
Graphic Jump Location

V.B.004

Marrow Iron. Marrow films. Prussian blue stains. (A) Absent marrow iron in a case of iron deficiency. No evidence of the blue reaction product indicative of marrow iron stores.(B) Intense staining of macrophage iron (blue reaction product in cytoplasm) in a case of lead poisoning. Although Prussian blue stain preferentially stains only one form of storage iron-proteinate, that is hemosiderin but not ferritin, its reactivity is a good assessment of marrow iron stores because marrow storage iron accumulation or loss occurs by parallel changes in both storage forms.

Want remote access to your institution's subscription?

Sign in to your MyAccess profile while you are actively authenticated on this site via your institution (you will be able to verify this by looking at the top right corner of the screen - if you see your institution's name, you are authenticated). Once logged in to your MyAccess profile, you will be able to access your institution's subscription for 90 days from any location. You must be logged in while authenticated at least once every 90 days to maintain this remote access.

Ok

About MyAccess

If your institution subscribes to this resource, and you don't have a MyAccess profile, please contact your library's reference desk for information on how to gain access to this resource from off-campus.

Pop-up div Successfully Displayed

This div only appears when the trigger link is hovered over. Otherwise it is hidden from view.