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V.J.001 Breast Carcinoma

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V.J.001

Metastatic breast carcinoma. Marrow film. Cluster of breast carcinoma cells.

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V.J.002 Breast Carcinoma

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V.J.002

Breast Carcinoma. Metastatic breast carcinoma. Marrow biopsy. This marrow biopsy shows poorly differentiated metastatic breast carcinoma from a patient with a history of infiltrating lobular carcinoma. Superficially, these tumor cells resemble plasma cells.

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V.J.003 Breast Carcinoma

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V.J.003

Metastatic Breast Carcinoma Cells. (A) Marrow concentrate film. Note large cells with very large nuclei and heavily vacuolated cytoplasm. (B) Marrow biopsy. Cluster of large cells with very large nuclei and bold nucleoli. Vacuolated cytoplasm around the nuclear outlines.

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V.J.004 Breast Carcinoma, CD138 Stain

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V.J.004

Metastatic breast cancer, CD138 stain. Marrow biopsy. CD138 (syndecan-1) stain. Although more often associated with plasma cells, CD138 expression can also be expressed by carcinoma cells. The tumor cells shown also stained for cytokeratin. No detectable kappa or lambda light chain expression was present on in situ hybridization studies.

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V.J.005 Breast Carcinoma, Cytokeratin Stain

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V.J.005

Metastatic breast cancer, cytokeratin stain. Cytokeratin immunohistochemistry stain on same marrow shown in Figure V.J.004 confirms that the tumor seen is metastatic carcinoma. Mixture of high and low molecular weight (AE-1/3 and Cam5.2) anticytokeratin antibodies was used, stained by standard peroxidase-antiperoxidase technique using 3-amino-9-ethylcarbazole substrate.

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V.J.006 Ewing Sarcoma

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V.J.006

Ewing Sarcoma. Marrow film. Very Large Ewing sarcoma cells. Most with scant cytoplasm and one with evident large nucleolus.

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V.J.007 Lung Carcinoma

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V.J.007

Metastatic lung carcinoma cells. Marrow film. A cluster of metastatic lung cells.

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V.J.008 Lung Carcinoma

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V.J.008

Metastatic Lung Carcinoma Cells. Marrow Sections. (A, B) Aggregates of metastatic small cell carcinoma of the lung cells. Note large size compared to neutrophil in (B) and tendency to aggregate.

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V.J.009 Prostate Cancer

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V.J.009

Metastatic prostatic carcinoma cells. Marrow film. A cluster of prostatic carcinoma cells.

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V.J.010 Neuroblastoma

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V.J.010

Neuroblastoma cells. Marrow film. Note characteristic rosette formation of neuroblastoma cells.

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V.J.011 Rhabdomyosarcoma

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