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VII.E.001 Hodgkin Lymphoma, Classical Type, Nodular Sclerosis Subtype

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VII.E.001

Hodgkin lymphoma, classical type, nodular sclerosis subtype. Lymph node. H&E. Note large bands of collagen fibrosis (asterisk) dividing the tumor into macronodules of polymorphous lymphohistiocytic infiltrate.

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VII.E.002 Hodgkin Lymphoma, Classical Type, Nodular Sclerosis Type

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VII.E.002

Classical Hodgkin lymphoma, nodular sclerosis type. Photograph illustrates numerous Reed-Sternberg cells with retraction artifact induced by formalin fixation (lacunar cell variant of Hodgkin cells).

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VII.E.003 Hodgkin Lymphoma

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VII.E.003

Hodgkin lymphoma. Lymph node biopsy. H&E stain, intermediate magnification, showing mixed lymphohistiocytic infiltrate with scattered large cells (Reed-Sternberg and Reed-Sternberg variant cells).

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VII.E.004 Hodgkin Lymphoma

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VII.E.004

Hodgkin lymphoma. Lymph node biopsy. H&E stain, Reed-Sternberg cell.

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VII.E.005 Hodgkin Lymphoma, CD30 Immunostain

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VII.E.005

Hodgkin lymphoma. CD30 immunostain Lymph node biopsy, Reed-Sternberg cells. Positive reaction manifest by reddish-brown reaction in the Reed-Sternberg and Reed-Sternberg variant cells. Reed-Sternberg cells are binucleate giant cells with very large nucleoli. Variant cells are usually mononuclear with somewhat smaller nucleoli.

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VII.E.006 Hodgkin Lymphoma, Classical Type, CD30 Immunostain

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VII.E.006

Hodgkin lymphoma, classical type. Lymph node biopsy. CD30 immunostain. The reddish-brown reaction product highlights the characteristic Reed-Sternberg (RS) cells.

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VII.E.007 Hodgkin Lymphoma, CD15 Immunostain

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VII.E.007

Hodgkin lymphoma. CD15 immunostain. Lymph node biopsy. Immunostain produces reddish-brown reaction product in the Reed-Sternberg and Reed-Sternberg variant cells.

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VII.E.008 Hodgkin Lymphoma, Classical Type, CD15 Immunostain

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VII.E.008

Hodgkin lymphoma, classical type. CD15 immunostain. Lymph node biopsy. Immunostain produces reddish-brown reaction product in the Reed-Sternberg and Reed-Sternberg variant cells.

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VII.E.009 Hodgkin Lymphoma, LCA Immunostain

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VII.E.009

Hodgkin lymphoma. Leukocyte common antigen (LCA) immunostain. Lymph node biopsy. Immunostain shows that large Reed-Sternberg cells are LCA-negative, with surrounding LCA-positive lymphocytes (reddish-brown cytoplasmic staining).

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VII.E.010 Hodgkin Lymphoma, Fascin Immunostain

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VII.E.010

Hodgkin lymphoma. Fascin stain. Lymph node biopsy. Reed-Sternberg cells react with stain but not the surrounding small lymphocytes.

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VII.E.011 Hodgkin Lympoma

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