der14 t(11;14)(q13;q32). G-banding. Arrow indicates the derivative 14 with elongated long arm.
t(14)(q32) FISH. Probes for 3-prime (red signal) and 5-prime (green signal) segments of the IgH gene. (A) Normal cell with two fused signals indicating normal juxtaposition of the 3 and 5 prime segments of the IgH gene on 14q32 (interphase preparation). (B) Abnormal cell. One fused signal and one red and green signal indicating translocation through IgH at chromosome 14q32 (interphase preparation).
Monosomy 13 (-13). G-banding. Arrow indicates monosomy of chromosome 13.
Monosomy 13 (-13). FISH. Probe for RB-1 of chromosome 13q14 (red). (A) Normal cell. Two red signals (interphase preparation). (B) Abnormal cell. One signal consistent with deletion of chromosome 13.
Monosomy 17 (-17). FISH. Probe for the P53 gene on 17p13.1 (red signal). (A) Normal cell with two red signals (interphase preparation). (B) Abnormal cell. One red signal compatible with loss of one chromosome 17.
Hyperdiploidy. G-banding. Trisomy 2, 3, 4, 7, 9, 11, 21, tetrasomy 15 and 19, and –Y.
Trisomy 9 And 11. FISH. Probes for centromeres of chromosome 9 (red) and chromosome 11 (green). (A) Normal cell. Two red and two green signals (interphase preparation). (B) Abnormal cell. Three red signals (three chromosomes 9) and three green signals three chromosomes 11 (interphase preparation).
Complex abnormalities. Arrows indicate abnormal chromosome 1, trisomy 3, 7, 11, 15, 19, monosomy 13, 20, structural abnormality of 21, and deleted Y chromosome.
der(5)t(5;17)(q13;q21) G banding. Unbalanced translocation of 5 with missing partner chromosome 17 resulting in monosomy 5q and monosomy 17p. Additional structural and numerical abnormalities including monosomy 4, 12, 13, and 17 and trisomy 10 and 21.