Skip to Main Content


X.D.001 Light Chains in Myeloma

Graphic Jump Location


In situ hybridization for light chains in a case of myeloma. Marrow. In situ hybridization for either kappa or lambda immunoglobulin light chain RNA was performed using biotin-labeled oligonucleotide probes, followed by a streptavidin-alkaline phosphatase detections system and colored substrate formation. In the left panel, the color reaction in the cytoplasm confirms that plasma cells express monoclonal kappa light chain as reflected in the intense cytoplasmic dark blue to black staining. In the right panel there is no reactivity of plasma cells with the lambda specific probe (absence of cytoplasmic staining). In a case in which plasma cells are synthesizing lambda light chains, the lambda reaction would be positive (cytoplasm dark blue to black) and the kappa reaction negative. This result is indicative of a clone of neoplastic plasma cells synthesizing a monoclonal kappa light chain.


X.D.002 Epstein-Barr Virus in Lymphoma

Graphic Jump Location


In situ hybridization for Epstein-Barr virus early RNA (EBER) in a case of plasmablastic lymphoma from an HIV-positive patient. Note the nuclear brown stain, reflecting the presence of EBER in the lymphoma cells.

Want remote access to your institution's subscription?

Sign in to your MyAccess profile while you are actively authenticated on this site via your institution (you will be able to verify this by looking at the top right corner of the screen - if you see your institution's name, you are authenticated). Once logged in to your MyAccess profile, you will be able to access your institution's subscription for 90 days from any location. You must be logged in while authenticated at least once every 90 days to maintain this remote access.


About MyAccess

If your institution subscribes to this resource, and you don't have a MyAccess profile, please contact your library's reference desk for information on how to gain access to this resource from off-campus.

Pop-up div Successfully Displayed

This div only appears when the trigger link is hovered over. Otherwise it is hidden from view.