Diagnosis, especially differentiation from iron-deficiency anemia (IDA), depends on laboratory findings (see Table 13–1):
— Initially normochromic, normocytic anemia; hypochromic, microcytic features develop as anemia progresses.
— Low serum iron level and somewhat decreased serum transferrin concentration; decreased percent saturation of transferrin.
— Level of serum ferritin, an acute phase protein, is inappropriately elevated (approximately threefold) with respect to storage iron.
— Marrow contains increased storage iron. The M/E ...