Sections View Full Chapter Figures Tables Videos Full Chapter Figures Tables Videos Supplementary Content ++ DEFINITIONS ++ Purpura is the extravasation of red cells from vasculature into the skin and/or subcutaneous tissues. Petechiae are lesions less than 2 mm in diameter. Purpura describes lesions 2 mm to 1 cm. Ecchymoses are lesions greater than 1 cm. Erythema is reddened skin due to increased capillary flow. Telangiectasia is dilated superficial capillaries. Erythema and telangiectasia blanch with pressure. This can be easily demonstrable with a glass microscope slide. ++ PATHOPHYSIOLOGY ++ Hemostatic mechanisms may be unable to protect against minor vascular trauma. Vessels and surrounding tissues may be weakened structurally. Transmural pressure gradient may be too great. Palpability may result from: — Extravascular fibrin deposition. — Cellular infiltration due to inflammation or malignancy. ++ NONPALPABLE PURPURA ++ Increased Transmural Pressure Gradient ++ Increased intrathoracic pressure caused by coughing, vomiting, weight lifting, etc., may cause petechiae of the face, neck, and upper thorax. Venous valvular incompetence or tight clothing may cause petechiae on the lower extremities. ++ Decreased Mechanical Integrity of the Microvasculature or Supporting Tissues ++ Actinic (senile) purpura is red to purple irregular patches on the extensor surfaces of the forearm and hands. Glucocorticoid excess causes bright red purpuric lesions in thin, fragile skin on flexor and extensor surfaces of both arms and legs. Vitamin C deficiency (scurvy) causes loss of collagen and ground substance in the skin, which leads to follicular hyperkeratosis, petechiae, perifollicular purpura with entrapped corkscrew hairs. Large ecchymoses and hemorrhagic gingivitis, stomatitis, and conjunctivitis may occur. Ehlers-Danlos syndrome is characterized by easy bruising in types IV and V, but this may occur with other types as well. Pseudoxanthoma elasticum may be associated with recurrent mucosal hemorrhages. In amyloidosis, infiltration of blood vessel walls may lead to increased vascular fragility and petechiae or purpura. The female easy-bruising syndrome (purpura simplex) is purpura or ecchymoses occurring predominantly in women, frequently on the thighs. This may be related to hormonal changes, and can be aggravated by nonsteroidal antiinflammatory drug (NSAID) ingestion. ++ TRAUMA ++ Physical trauma can cause cutaneous bleeding. The history, shape, and location of the lesions may suggest the etiology. Factitial purpura usually presents as medium to large ecchymoses on the lower extremities of patients who appear unconcerned about the lesions. ++ SUNBURN ++ Acute sunburn may be sufficiently severe to have a petechial component. ++ INFECTIONS ++ Purpura may occur with bacterial, fungal, viral, or rickettsial infections, or with parasitic infestations, including protozoan, often as a consequence of a complex, multifactorial process. Special forms include: — Bacterial sepsis due to various organisms can cause petechiae or purpura, macules or papules, hemorrhagic bullae, erosions, ulcers, or widespread ecchymoses and cutaneous infarctions (purpura fulminans, see below). — Ecthyma gangrenosum may accompany infections with Pseudomonas sp., Klebsiella sp., Aeromona hydrophilia, or Escherichia coli in patients with ... GET ACCESS TO THIS RESOURCE Sign In Username Error: Please enter User Name Password Error: Please enter Password Forgot Username? Forgot Password? Sign in via OpenAthens Sign in via Shibboleth Get Free Access Through Your Institution Contact your institution's library to ask if they subscribe to McGraw-Hill Medical Products. What is MyAccess? Create a FREE MyAccess profile to: Use this site remotely Bookmark your favorite content Track your self-assessment progress and more!