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Contributors
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James L. Abbruzzese, MD

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Professor and Chair, Department of GI Medical Oncology;

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M.G. and Lillie Johnson Chair for Cancer Treatment and Research,

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University of Texas, MD Anderson Cancer Center, Houston, Texas [47]

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John W. Adamson, MD

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Clinical Professor of Medicine, Department of Hematology/Oncology,

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University of California, San Diego, San Diego, California [2, 7]

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Kenneth C. Anderson, MD

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Kraft Family Professor of Medicine, Harvard Medical School;

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Chief, Jerome Lipper Multiple Myeloma Center,

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Dana-Farber Cancer Institute, Boston, Massachusetts [12, 17]

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Frederick R. Appelbaum, MD

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Director, Division of Clinical Research,

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Fred Hutchinson Cancer Research Center, Seattle, Washington [30]

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Wiebke Arlt, MD, DSc, FRCP, FMedSci

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Professor of Medicine, Centre for Endocrinology, Diabetes and Metabolism,

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School of Clinical and Experimental Medicine,

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University of Birmingham; Consultant Endocrinologist,

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University Hospital Birmingham, Birmingham, United Kingdom [51]

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Valder R. Arruda, MD, PhD

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Associate Professor of Pediatrics,

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University of Pennsylvania School of Medicine;

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Division of Hematology, The Children's Hospital of Philadelphia,

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Philadelphia, Pennsylvania [20]

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Robert C. Basner, MD

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Professor of Clinical Medicine, Division of Pulmonary,

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Allergy, and Critical Care Medicine,

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Columbia University College of Physicians and Surgeons,

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New York, New York [Appendix]

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Robert S. Benjamin, MD

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P.H. and Fay E. Robinson Distinguished Professor and Chair,

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Department of Sarcoma Medical Oncology,

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University of Texas MD Anderson Cancer Center, Houston, Texas [45]

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Edward J. Benz, Jr., MD

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Richard and Susan Smith Professor of Medicine,

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Professor of Pediatrics, Professor of Genetics,

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Harvard Medical School; President and CEO, Dana-Farber Cancer Institute;

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Director, Dana-Farber/ Harvard Cancer Center (DF/HCC), Boston, Massachusetts [8]

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Clara D. Bloomfield, MD

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Distinguished University Professor; William G. Pace, III

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Professor of Cancer Research; Cancer Scholar and Senior Advisor,

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The Ohio State University Comprehensive Cancer Center;

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Arthur G. James Cancer Hospital and Richard J. Solove Research Institute,

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Columbus, Ohio [14]

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George J. Bosl, MD

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Professor of Medicine, Weill Cornell Medical College;

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Chair, Department of Medicine; Patrick M. Byrne Chair in Clinical Oncology,

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Memorial Sloan-Kettering Cancer Center, New York, New York [43]

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Otis W. Brawley, MD

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Chief Medical Officer, American Cancer Society Professor of Hematology,

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Oncology, Medicine, and Epidemiology, Emory University, Atlanta, Georgia [27]

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Cynthia D. Brown, MD

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Assistant Professor of Medicine,

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Division of Pulmonary and Critical Care Medicine,

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University of Virginia, Charlottesville,

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Virginia [Review and Self-Assessment]

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Brian I. Carr, MD, PhD, FRCP

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Professor of Oncology and Hepatology,

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IRCCS De Bellis Medical Research Institute,

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Castellana Grotte, Italy [39]

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Irene Chong, MRCP, FRCR

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Clinical Research Fellow, Royal Marsden NHS Foundation Trust,

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London and Sutton, United Kingdom [40]

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Francis S. Collins, MD, PhD

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Director, National Institutes of Health,

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Bethesda, Maryland [24]

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Jennifer M. Croswell, MD, MPH

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Acting Director, Office of Medical Applications of Research,

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National Institutes of Health, Bethesda, Maryland [27]

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David Cunningham, MD, FRCP

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Professor of Cancer Medicine, Royal Marsden NHS Foundation Trust,

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London and Sutton, United Kingdom [40]

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Josep Dalmau, MD, PhD

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ICREA Research Professor, Institute for Biomedical Investigations,

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August Pi i Sunyer (IDIBAPS)/Hospital Clinic,

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Department of Neurology, University of Barcelona, Barcelona, Spain;

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Adjunct Professor of Neurology University of Pennsylvania,

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Philadelphia, Pennsylvania [53]

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Lisa M. DeAngelis, MD

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Professor of Neurology, Weill Cornell Medical College;

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Chair, Department of Neurology, Memorial Sloan-Kettering Cancer Center,

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New York, New York [46]

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Janice Dutcher, MD

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Department of Oncology, New York Medical College,

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Montefiore, Bronx, New York [54]

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Jeffery S. Dzieczkowski, MD

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Physician, St. Alphonsus Regional Medical Center;

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Medical Director, Coagulation Clinic, Saint Alphonsus Medical Group,

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International Medicine and Travel Medicine, Boise, Idaho [12]

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Andrew J. Einstein, MD, PhD

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Assistant Professor of Clinical Medicine,

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Columbia University College of Physicians and Surgeons;

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Department of Medicine, Division of Cardiology,

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Department of Radiology, Columbia University Medical Center and

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New York-Presbyterian Hospital, New York, New York [Appendix]

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Ezekiel J. Emanuel, MD, PhD

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Vice Provost for Global Initiatives and Chair,

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Department of Medical Ethics and Health Policy,

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University of Pennsylvania, Philadelphia, Pennsylvania [32]

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Robert Finberg, MD

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Chair, Department of Medicine,

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University of Massachusetts Medical School,

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Worcester, Massachusetts [29]

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Jane E. Freedman, MD

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Professor, Department of Medicine,

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University of Massachusetts Medical School,

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Worcester, Massachusetts [21]

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Carl E. Freter, MD, PhD

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Professor, Department of Internal Medicine,

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Division of Hematology/Medical Oncology,

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University of Missouri; Ellis Fischel Cancer Center,

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Columbia, Missouri [55]

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Robert F. Gagel, MD

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Professor of Medicine and Head,

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Division of Internal Medicine,

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University of Texas MD Anderson Cancer Center,

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Houston, Texas [50]

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John I. Gallin, MD

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Director, Clinical Center,

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National Institutes of Health,

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Bethesda, Maryland [5]

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Samuel Z. Goldhaber, MD

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Professor of Medicine, Harvard Medical School;

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Director, Venous Thromboembolism Research Group,

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Cardiovascular Division, Brigham and Women's Hospital,

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Boston, Massachusetts [22]

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Rasim Gucalp, MD

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Professor of Clinical Medicine,

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Albert Einstein College of Medicine;

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Associate Chairman for Educational Programs,

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Department of Oncology; Director, Hematology/Oncology Fellowship,

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Montefiore Medical Center, Bronx, New York [54]

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Anna R. Hemnes, MD

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Assistant Professor, Division of Allergy,

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Pulmonary, and Critical Care Medicine,

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Vanderbilt University Medical Center,

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Nashville, Tennessee [Review and Self-Assessment]

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Patrick H. Henry, MD

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Clinical Adjunct Professor of Medicine,

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University of Iowa, Iowa City, Iowa [4]

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Katherine A. High, MD

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Investigator, Howard Hughes Medical Institute;

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William H. Bennett Professor of Pediatrics,

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University of Pennsylvania School of Medicine;

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Director, Center for Cellular and Molecular Therapeutics,

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Children's Hospital of Philadelphia, Philadelphia, Pennsylvania [20]

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A. Victor Hoffbrand, DM

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Professor Emeritus of Haematology,

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University College, London; Honorary Consultant Haematologist,

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Royal Free Hospital, London, United Kingdom [9]

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Steven M. Holland, MD

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Chief, Laboratory of Clinical Infectious Diseases,

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National Institute of Allergy and Infectious Diseases,

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National Institutes of Health, Bethesda, Maryland [5]

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Leora Horn, MD, MSc

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Division of Hematology and Medical Oncology,

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Vanderbilt University School of Medicine, Nashville, Tennessee [35]

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J. Larry Jameson, MD, PhD

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Robert G. Dunlop Professor of Medicine; Dean,

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University of Pennsylvania School of Medicine;

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Executive Vice President of the University of Pennsylvania for the Health System,

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Philadelphia, Pennsylvania [48, 52]

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Robert T. Jensen, MD

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Digestive Diseases Branch, National Institute of Diabetes;

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Digestive and Kidney Diseases, National Institutes of Health,

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Bethesda, Maryland [49]

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David H. Johnson, MD, FACP

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Donald W. Seldin Distinguished Chair in Internal Medicine;

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Professor and Chairman, Department of Internal Medicine,

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University of Texas Southwestern Medical School, Dallas, Texas [35]

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Barbara Konkle, MD

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Professor of Medicine, Hematology, University of Washington;

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Director, Translational Research, Puget Sound Blood Center,

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Seattle, Washington [3, 19]

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Barnett S. Kramer, MD, MPH

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Director, Division of Cancer Prevention,

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National Cancer Institute, Bethesda, Maryland [27]

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Alexander Kratz, MD, PhD, MPH

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Associate Professor of Pathology and Cell Biology,

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Columbia University College of Physicians and Surgeons;

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Director, Core Laboratory, Columbia University Medical Center,

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New York, New York [Appendix]

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Marc E. Lippman, MD, MACP

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Kathleen and Stanley Glaser Professor;

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Chairman, Department of Medicine, Deputy Director,

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Sylvester Comprehensive Cancer Center,

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University of Miami Miller School of Medicine,

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Miami, Florida [37]

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Dan L. Longo, MD

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Professor of Medicine, Harvard Medical School;

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Senior Physician, Brigham and Women's Hospital;

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Deputy Editor, New England Journal of Medicine,

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Boston, Massachusetts [1, 2, 4, 6, 15, 16, 17, 25, 26, 28, 31, 36, 51, 52, 55]

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Joseph Loscalzo, MD, PhD

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Hersey Professor of the Theory and Practice of Medicine,

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Harvard Medical School; Chairman, Department of Medicine;

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Physician-in-Chief, Brigham and Women's Hospital, Boston,

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Massachusetts [21]

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Lucio Luzzatto, MD, FRCP, FRCPath

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Professor of Haematology, University of Genova,

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Scientific Director Istituto Toscano Tumori, Italy [10]

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Guido Marcucci, MD

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Professor of Medicine;

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John B. and Jane T. McCoy Chair in Cancer Research;

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Associate Director of Translational Research, Comprehensive Cancer Center,

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The Ohio State University College of Medicine, Columbus, Ohio [14]

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Robert J. Mayer, MD

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Stephen B. Kay Family Professor of Medicine,

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Harvard Medical School, Boston, Massachusetts [38]

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Pat J. Morin, PhD

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Senior Investigator,

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Laboratory of Molecular Biology and Immunology,

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National Institute on Aging,

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National Institutes of Health, Baltimore, Maryland [24]

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Robert J. Motzer, MD

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Professor of Medicine, Weill Cornell Medical College;

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Attending Physician, Genitourinary Oncology Service,

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Memorial Sloan-Kettering Cancer Center, New York, New York [41, 43]

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Nikhil C. Munshi, MD

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Associate Professor of Medicine, Harvard Medical School;

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Associate Director, Jerome Lipper Multiple Myeloma Center,

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Dana Farber Cancer Institute, Boston, Massachusetts [17]

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Hari Nadiminti, MD

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Clinical Instructor, Department of Dermatology,

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Emory University School of Medicine, Atlanta, Georgia [33]

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Hartmut P. H. Neumann, MD

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Head, Section Preventative Medicine,

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Department of Nephrology and General Medicine,

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Albert-Ludwigs-University of Freiburg, Germany [51]

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William Pao, MD, PhD

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Associate Professor of Medicine, Cancer Biology,

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and Pathology, Division of Hematology and Medical Oncology,

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Vanderbilt University School of Medicine, Nashville, Tennessee [35]

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Shreyaskumar R. Patel, MD

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Center Medical Director, Sarcoma Center;

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Professor of Medicine;

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Deputy Chairman, Department of Sarcoma Medical Oncology,

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MD Anderson Cancer Center, Houston, Texas [45]

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Michael A. Pesce, PhD

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Professor Emeritus of Pathology and Cell Biology,

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Columbia University College of Physicians and Surgeons;

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Columbia University Medical Center, New York, New York [Appendix]

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Myrna R. Rosenfeld, MD, PhD

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Professor of Neurology and Chief,

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Division of Neuro-oncology,

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University of Pennsylvania, Philadelphia, Pennsylvania [53]

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Edward A. Sausville, MD, PhD

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Professor, Department of Medicine,

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University of Maryland School of Medicine;

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Deputy Director and Associate Director for Clinical Research,

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University of Maryland Marlene and Stewart Greenebaum Cancer Center,

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Baltimore, Maryland [28]

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David T. Scadden, MD

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Gerald and Darlene Jordan Professor of Medicine,

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Harvard Stem Cell Institute, Harvard Medical School;

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Department of Stem Cell and Regenerative Biology,

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Massachusetts General Hospital, Boston, Massachusetts [1]

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Howard I. Scher, MD

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Professor of Medicine, Weill Cornell Medical College;

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D. Wayne Calloway Chair in Urologic Oncology;

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Chief, Genitourinary Oncology Service,

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Department of Medicine, Memorial Sloan-Kettering Cancer Center,

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New York, New York [41, 42]

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Michael V. Seiden, MD, PhD

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Professor of Medicine;

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President and CEO, Fox Chase Cancer Center,

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Philadelphia, Pennsylvania [44]

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David C. Seldin, MD, PhD

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Chief, Section of Hematology-Oncology,

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Department of Medicine; Director,

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Amyloid Treatment and Research Program,

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Boston University School of Medicine;

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Boston Medical Center, Boston, Massachusetts [18]

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Martha Skinner, MD

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Professor, Department of Medicine,

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Boston University School of Medicine,

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Boston, Massachusetts [18]

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Jerry L. Spivak, MD

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Professor of Medicine and Oncology,

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Hematology Division, Johns Hopkins University School of Medicine,

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Baltimore, Maryland [13]

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Jeffrey M. Trent, PhD, FACMG

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President and Research Director,

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Translational Genomics Research Institute, Phoenix, Arizona;

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Van Andel Research Institute, Grand Rapids, Michigan [24]

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Walter J. Urba, MD, PhD

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Director of Cancer Research,

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Robert W. Franz Cancer Research Center,

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Providence Portland Medical Center,

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Portland, Oregon [33]

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Gauri R. Varadhachary, MD

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Associate Professor,

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Department of Gastrointestinal Medical Oncology,

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University of Texas MD Anderson Cancer Center,

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Houston, Texas [47]

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Camilo Jimenez Vasquez, MD

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Assistant Professor,

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Department of Endocrine Neoplasia and Hormonal Disorders,

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Division of Internal Medicine,

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University of Texas MD Anderson Cancer Center, Houston, Texas [50]

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Bert Vogelstein, MD

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Professor of Oncology and Pathology;

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Investigator, Howard Hughes Medical Institute;

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Sidney Kimmel Comprehensive Cancer Center;

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Johns Hopkins University School of Medicine,

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Baltimore, Maryland [24]

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Everett E. Vokes, MD

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John E. Ultmann Professor and Chairman,

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Department of Medicine; Physician-in-Chief,

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University of Chicago Medical Center, Chicago, Illinois [34]

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Carl V. Washington, MD

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Associate Professor of Dermatology,

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Winship Cancer Center, Emory University School of Medicine,

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Atlanta, Georgia [33]

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Anthony P. Weetman, MD

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University of Sheffield School of Medicine,

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Sheffield, United Kingdom [48]

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Jeffrey I. Weitz, MD, FRCP(C), FACP

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Professor of Medicine and Biochemistry;

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Executive Director, Thrombosis and Atherosclerosis Research Institute;

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HSFO/J. F. Mustard Chair in Cardiovascular Research,

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Canada Research Chair (Tier 1) in Thrombosis,

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McMaster University, Hamilton, Ontario, Canada [23]

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Patrick Y. Wen, MD

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Professor of Neurology, Harvard Medical School;

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Dana-Farber Cancer Institute, Boston, Massachusetts [46]

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Meir Wetzler, MD, FACP

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Professor of Medicine, Roswell Park Cancer Institute,

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Buffalo, New York [14]

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Charles M. Wiener, MD

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Dean/CEO Perdana University Graduate School of Medicine,

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Selangor, Malaysia; Professor of Medicine and Physiology,

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Johns Hopkins University School of Medicine,

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Baltimore, Maryland [Review and Self-Assessment]

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Neal S. Young, MD

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Chief, Hematology Branch, National Heart, Lung and Blood Institute,

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National Institutes of Health, Bethesda, Maryland [11]

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