Combination chemotherapy uses several drugs simultaneously based on certain empiric principles:
— Each drug selected has demonstrable antitumor activity against the neoplasm for which it is used.
— Each drug should have a different mechanism of action.
— The drugs should not have a common mechanism of resistance.
— Drug dose-limiting toxicities should not overlap.
— Specific combinations chosen should be based on preclinical and clinical protocol-based evidence of synergistic activity.