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CLASSIFICATION

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  • Lymphocyte malignancies comprise a wide spectrum of different morphologic and clinical syndromes.

  • The International Lymphoma Study Group proposed a new classification termed Revised European–American Lymphoma classification, or REAL classification, which was modified in 2001 and updated in 2008 by the World Health Organization (WHO) (see Table 53–1).

  • The REAL/WHO classification makes use of the pathologic, immunophenotypic, genetic, and clinical features to define separate disease entities (Table 53–1).

  • Lymphocytic neoplasms are divided into those derived from B cells, T cells, or natural killer (NK) cells.

  • The immunophenotype and the characteristic cytogenetic and genic abnormalities are also included in Table 53–1.

  • The most common indolent and aggressive lymphocytic neoplasms, based on their usual clinical behavior, are listed in Tables 53–2 and 53–3.

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TABLE 53–1CLASSIFICATION OF LYMPHOMA AND LYMPHOID LEUKEMIA BY THE WORLD HEALTH ORGANIZATION

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