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Introduction to Blood and Hematopoiesis

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Which of the following is not true of the spleen in normal individuals?

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A. It serves as a filter for the blood.

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B. It is an important source of immunoglobulins.

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C. It is enlarged in many conditions associated with acute or chronic activation of the immune system.

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D. It is an important source of formed blood elements.

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E. It is a rare site of primary tumor development.

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In normal humans, the spleen is primarily a lymphoid and macrophage organ and contains a paucity of hematopoietic and progenitor and precursor cells. (The answer is D.)

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Which of the following is not true of lymph nodes?

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A. They filter the lymph.

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B. They contain mainly B cells and few T cells.

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C. They may become painfully enlarged in acute immune reactions.

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D. They are a source of immunoglobulins.

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E. They contain numerous antigen-presenting cells.

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Lymph nodes contain B lymphocytes concentrated within follicles called germinal centers. Between these germinal centers and within the central part of the node the predominant cells are T lymphocytes. (The answer is B.)

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Which of the following is not true of the bone marrow?

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A. It serves as the major source of formed blood elements after birth.

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B. In patients who are suspected of having metastatic carcinoma, examination of the marrow may be useful in establishing a tissue diagnosis.

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C. It is often examined to determine the cause of pancytopenia.

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D. It is the primary site of hematopoiesis during embryonic development.

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E. It contains fat cells that may negatively regulate hematopoiesis.

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F. It contains a niche that nurtures stem cells.

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During embryonic development, the primary sites of hematopoiesis are the yolk sac, the mesonephros, and the liver. (The answer is D.)

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Which of the following is not true of hematopoietic growth factors?

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A. Thrombopoietin production increases in response to thrombocytopenia.

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B. Erythropoietin production increases in response to blood loss.

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