TY  - CHAP
M1  - Book, Section
TI  - Melanoma
A1  - Kim, Dae Won
A1  - Gershenwald, Jeffrey E.
A1  - Patel, Sapna P.
A1  - Davies, Michael A.
A2  - Kantarjian, Hagop M.
A2  - Wolff, Robert A.
PY  - 2016
T2  - The MD Anderson Manual of Medical Oncology, 3e
AB  - Melanoma  is  the  most  aggressive  form  of  skin  cancer.  Although  its  incidence  pales  in  comparison  to  basal  cell  carcinoma  and  squamous  cell  carcinoma  (SCC),  melanoma  is  the  cause  of  approximately  75%  of  all  skin  cancer–related  deaths.  The  majority  of  patients  who  are  diagnosed  with  early-stage  melanoma  have  very  good  outcomes  with  appropriate  surgical  management.  In  contrast,  patients  with  regional  and  distant  metastases  have  historically  had  poorer  outcomes,  because  agents  that  have  proven  efficacious  in  other  malignancies  (eg,  chemotherapy)  generally  have  had  limited  activity  in  this  disease.  However,  the  management  of  melanoma  is  evolving  rapidly  due  to  parallel  breakthroughs  in  the  understanding  and  targeting  of  the  molecular  drivers  of  this  disease  and  the  regulators  of  the  antitumor  immune  response.  These  advances  are  rapidly  translating  into  improved  outcomes  in  patients  with  advanced  melanoma  and  the  consideration  of  new  diagnostic  and  therapeutic  approaches  across  the  full  continuum  of  this  disease.  
SN  - 
PB  - McGraw-Hill Medical
CY  - New York, NY
Y2  - 2024/04/20
UR  - hemonc.mhmedical.com/content.aspx?aid=1126745074
ER  -