TY  - CHAP
M1  - Book, Section
TI  - ENDOCRINE TUMORS OF THE GASTROINTESTINAL TRACT AND PANCREAS
A1  - Jensen, Robert T.
A2  - Longo, Dan L.
PY  - 2013
T2  - Harrison's Hematology and Oncology, 2e
AB  - Gastrointestinal  (GI)  neuroendocrine  tumors  (NETs)  are  tumors  derived  from  the  diffuse  neuroendocrine  system  of  the  GI  tract;  that  system  is  composed  of  amine-  and  acid-producing  cells  with  different  hormonal  profiles,  depending  on  the  site  of  origin.  The  tumors  historically  are  divided  into  carcinoid  tumors  and  pancreatic  endocrine  tumors  (PETs),  although  recent  pathologic  classifications  have  proposed  that  they  all  be  classified  as  gastrointestinal  NETs.  In  this  chapter,  the  term  carcinoid  tumor  is  retained  because  it  is  widely  used.  These  tumors  originally  were  classified  as  APUDomas  (for  amine  precursor  uptake  and  decarboxylation),  as  were  pheochromocytomas,  melanomas,  and  medullary  thyroid  carcinomas  because  they  share  certain  cytochemical  features  as  well  as  various  pathologic,  biologic,  and  molecular  features  (Table  49-1).  It  was  originally  proposed  that  APUDomas  had  a  similar  embryonic  origin  from  neural  crest  cells,  but  it  is  now  known  the  peptide-secreting  cells  are  not  of  neuroectodermal  origin.  Nevertheless,  the  concept  of  APUDomas  is  useful  because  the  tumors  from  the  cells  have  important  similarities  as  well  as  some  differences  (Table  49-1).  In  this  section,  the  areas  of  similarity  between  PETs  and  carcinoids  will  be  discussed  together  and  areas  in  which  there  are  important  differences  will  be  discussed  separately.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/20
UR  - hemonc.mhmedical.com/content.aspx?aid=1128358061
ER  -