TY - CHAP M1 - Book, Section TI - Functions of Natural Killer Cells A1 - Trinchieri, Giorgio A1 - Childs, Richard W. A1 - Lanier, Lewis L. A2 - Kaushansky, Kenneth A2 - Lichtman, Marshall A. A2 - Prchal, Josef T. A2 - Levi, Marcel M. A2 - Press, Oliver W. A2 - Burns, Linda J. A2 - Caligiuri, Michael PY - 2015 T2 - Williams Hematology, 9e AB - SUMMARYNatural killer (NK) cells, with a predominant morphology of large granular lymphocytes, represent a lineage of lymphoid cells with constitutive ability to mediate cytotoxicity toward pathologic target cells and secrete cytokines. NK cells participate in the innate resistance to microbial pathogens and malignancies; opposing effects of activating and inhibitory receptors regulate NK cell activity. Malignant expansions of NK cells, either acute or chronic, are rare, but represent well-identified clinical entities. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/19 UR - hemonc.mhmedical.com/content.aspx?aid=1121097265 ER -