TY  - CHAP
M1  - Book, Section
TI  - Polycythemia Vera
A1  - Lichtman, Marshall A.
A1  - Kaushansky, Kenneth
A1  - Kipps, Thomas J.
A1  - Prchal, Josef T.
A1  - Levi, Marcel M.
PY  - 2011
T2  - Williams Manual of Hematology, 8e
AB  - Polycythemia  vera  (PV)  is  a  clonal  disorder  due  to  somatic  mutations  of  a  multipotential  hematopoietic  cell,  in  which  blood  cell  production,  notably  erythropoiesis,  is  increased  independent  of  cytokine  regulation.  This  results  in  exaggerated  proliferation  and  accumulation  of  erythrocytic,  granulocytic,  and  megakaryocytic  cells.  PV  is  one  of  the  chronic  myeloproliferative  disorders  (MPDs):  essential  thrombocythemia  (ET),  primary  myelofibrosis  (PMF),  and  chronic  myelogenous  leukemia  (CML);  these  disorders  are  also  called  myeloproliferative  neoplasms  (MPN).Three  myeloproliferative  neoplasms  (PV,  ET,  PMF)  share  a  common  molecular  abnormality/marker,  the  JAK2  kinase  V617F  mutation.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/24
UR  - hemonc.mhmedical.com/content.aspx?aid=1126652604
ER  -