RT Book, Section
A1 Beutler, Lisa
A1 Babik, Jennifer
A2 Kaushansky, Kenneth
A2 Lichtman, Marshall A.
A2 Prchal, Josef T.
A2 Levi, Marcel M.
A2 Press, Oliver W.
A2 Burns, Linda J.
A2 Caligiuri, Michael
SR Print(0)
ID 1121090720
T1 Treatment of Infections in the Immunocompromised Host
T2 Williams Hematology, 9e
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071833004
LK hemonc.mhmedical.com/content.aspx?aid=1121090720
RD 2024/04/20
AB SUMMARYInfection  is  a  major  cause  of  morbidity  and  mortality  in  patients  with  severe  inherited  or  acquired  neutropenia  or  aplastic  anemia,  qualitative  disorders  of  neutrophils,  and,  notably,  those  persons  receiving  chemotherapy  for  treatment  of  hematologic  neoplasms.  Severe  neutropenia  and  monocytopenia  often  result  from  the  combined  effects  of  replacement  of  marrow  with  malignant  cells  and  superimposed  intense  chemotherapy.  The  severity  and  duration  of  the  neutropenia  determine  the  risk  of  infection.  Bacterial  infections  may  result  in  rapid  clinical  deterioration  and  even  death.  Fungal,  viral,  and  parasitic  infections  also  may  result  in  potentially  lethal  complications  during  or  after  chemotherapy.  This  chapter  considers  methods  of  diagnosis  of  bacterial,  fungal,  viral,  and  protozoal  infection  and  describes  treatment  regimens.  Because  prevention  of  infection  during  periods  of  neutropenia  should  reduce  morbidity  and  improve  outcome,  attention  is  focused  on  prophylaxis  against  bacterial,  parasitic,  viral,  and/or  fungal  infections.