RT Book, Section
A1 Beutler, Bruce
A2 Kaushansky, Kenneth
A2 Lichtman, Marshall A.
A2 Prchal, Josef T.
A2 Levi, Marcel M.
A2 Press, Oliver W.
A2 Burns, Linda J.
A2 Caligiuri, Michael
SR Print(0)
ID 1121090051
T1 Innate Immunity
T2 Williams Hematology, 9e
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071833004
LK hemonc.mhmedical.com/content.aspx?aid=1121090051
RD 2024/04/19
AB SUMMARYThe  innate  immune  system  provides  immediate  protection  against  infection  and  serves  an  essential  antigen-presenting  role  that  allows  the  adaptive  immune  response  to  occur  during  the  days  and  weeks  that  follow.  The  sensory  apparatus  that  allows  detection  of  infectious  microbes  has  been  deciphered  in  large  part,  and  it  is  now  known  that  Toll-like  receptors,  NOD-like  receptors,  RIG-I–like  helicases,  C-type  lectin  receptors,  and  cytosolic  sensors  of  DNA,  most  notably  cyclic  guanosine  monophosphate/adenosine  monophosphate  synthetase,  permit  recognition  of  specific  molecules  of  microbial  origin.  Much  has  also  been  learned  of  the  biochemical  events  that  follow  activation  of  these  sensors.  Susceptibility  to  infection  in  humans  is  strongly  heritable,  and  among  the  many  loci  that  influence  it,  those  that  encode  proteins  vital  to  the  innate  immune  response  are  of  central  importance.  Moreover,  autoinflammatory  and  autoimmune  diseases  are  dependent  upon  the  activation  of  innate  immune  signaling  pathways.