RT Book, Section
A1 MA, Lichtman
A1 MS, Shafer
A1 RE, Felgar
A1 N, Wang
SR Print(0)
ID 1138037119
T1 Red Cell Alterations in Non-Clonal Hematological Disorders
T2 Lichtman's Atlas of Hematology 2016
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9780071602679
LK hemonc.mhmedical.com/content.aspx?aid=1138037119
RD 2024/04/24
AB Graphic  Jump  LocationView  Full  Size||Download  Slide  (.ppt)I.C.001Abetalipoproteinemia.  Blood  film.  Patients  with  this  inherited  absence  of  products  of  the  apolipoprotein  B  gene  characteristically  have  over  50%  acanthocytes,  red  cells  with  irregular,  sharp  projections,  in  the  blood.  The  red  cell  membrane  abnormality  is  thought  to  reflect  an  excess  of  sphingomyelin  in  the  outer  leaflet  of  the  membrane  lipid  bilayer,  leading  to  excess  surface  area  and  sharp,  irregular,  spike  like  folds  in  the  red  cell  surface.  Erythroblasts  do  not  display  the  abnormality  and  circulating  cells  develop  it  as  they  age  in  the  circulation.