RT Book, Section
A1 Lichtman, Marshall A.
A1 Kaushansky, Kenneth
A1 Kipps, Thomas J.
A1 Prchal, Josef T.
A1 Levi, Marcel M.
SR Print(0)
ID 1126652861
T1 Classification of the Polyclonal Lymphoid Disorders
T2 Williams Manual of Hematology, 8e
YR 2011
FD 2011
PB McGraw-Hill Education
PP New York, NY
SN 9780071622424
LK hemonc.mhmedical.com/content.aspx?aid=1126652861
RD 2024/04/23
AB Polyclonal  lymphocyte  and  plasma  cell  disorders  can  be  classified  into  two  major  groups  (Table  49–1):—  Primary  disorders  that  result  from  defects  intrinsic  to  B  lymphocytes  (e.g.,  X-linked  agammaglobulinemia),  T  lymphocytes  (e.g.,  congenital  thymic  aplasia),  and/or  natural  killer  cells,  the  latter  usually  coupled  with  a  B  or  T  cell  deficiency  (e.g.,  interleukin  (IL)-7  receptor  α-chain  deficiency)  (see  Chap.  51).—  Acquired  disorders  that  result  from  physiologic  or  pathophysiologic  responses  to  extrinsic  factors,  usually  infectious  agents  (e.g.,  Epstein-Barr  virus  or  human  immunodeficiency  virus  infection).  (See  Chaps.  50,  52,  53.)The  monoclonal  lymphoid  disorders  are  classified  in  Chap.  54  and  individual  neoplastic  lymphoid  diseases  are  described  in  Chaps.  55–72.—  Disparate  disorders  can  have  similar  clinical  manifestations,  such  as  recurrent  infections  as  a  result  of  either  B  or  T  cell  deficiency.Lymphocyte  disorders  can  have  clinical  manifestations  that  are  not  restricted  to  cells  of  the  immune  system  (e.g.,  leprosy  or  systemic  lupus  erythematosus).In  some  cases,  classification  is  influenced  by  disease  manifestations:—  Diseases  caused  by  production  of  pathologic  autoantibodies;  e.g.,  autoimmune  hemolytic  disease  (see  Chaps.  24–26),  autoimmune  thrombocytopenia  (see  Chap.  120),  and  systemic  autoimmune  diseases  (e.g.,  myasthenia  gravis).—  Diseases  caused  by  excess  production  of  lymphocyte  cytokines;  e.g.,  chronic  inflammatory  disorders.