RT Book, Section
A1 Lichtman, Marshall A.
A1 Kaushansky, Kenneth
A1 Kipps, Thomas J.
A1 Prchal, Josef T.
A1 Levi, Marcel M.
SR Print(0)
ID 1126654750
T1 Hemostatic Dysfunction Related to Liver Diseases
T2 Williams Manual of Hematology, 8e
YR 2011
FD 2011
PB McGraw-Hill Education
PP New York, NY
SN 9780071622424
LK hemonc.mhmedical.com/content.aspx?aid=1126654750
RD 2024/04/25
AB Loss  of  hepatic  parenchymal  cells  leads  to  decreased  plasma  levels  of  all  plasma  coagulation  factors  except  factor  VIII  and  von  Willebrand  factor.Thrombocytopenia  occurs  frequently  and  is  usually  a  result  of  splenic  sequestration  (see  Chap.  74),  but  may  also  be  caused  by  an  autoimmune  mechanism,  disseminated  intravascular  coagulation  (DIC),  folic  acid  deficiency,  and  decreased  platelet  production.  In  some  patients,  thrombocytopenia  due  to  thrombopoietin  (TPO)  deficiency  and  platelet  dysfunction  contribute  to  the  hemostatic  abnormalities.Enhanced  fibrinolysis  is  common,  and  appears  to  be  caused  by  complex  pathogenetic  mechanisms,  including  release  and  impaired  clearance  of  plasminogen  activators.Dysfibrinogenemia  is  relatively  frequently  found  in  patients  with  chronic  liver  disease.Patients  with  chronic  liver  disease  may  develop  DIC.