RT Book, Section
A1 Chihara, Dai
A1 Wang, Casey
A1 Duvic, Madeleine
A1 Medeiros, L. Jeffrey
A1 Oki, Yasuhiro
A2 Kantarjian, Hagop M.
A2 Wolff, Robert A.
SR Print(0)
ID 1126740719
T1 T-Cell Lymphomas
T2 The MD Anderson Manual of Medical Oncology, 3e
YR 2016
FD 2016
PB McGraw-Hill Medical
PP New York, NY
SN 9780071847940
LK hemonc.mhmedical.com/content.aspx?aid=1126740719
RD 2024/04/20
AB Peripheral  T-cell  lymphoma  (PTCL)  is  a  heterogeneous  group  of  lymphomas  derived  from  a  mature  T  cell  (Fig.  9-1).  Currently,  the  World  Health  Organization  (WHO)  classification  combines  mature  T-  and  natural  killer  (NK)-cell  neoplasms  under  the  umbrella  term  PTCL,  and  the  category  is  composed  of  23  different  entities  (Table  9-1),  based  on  the  different  morphologic,  phenotypic,  molecular,  and  clinical  features,  including  disease  site  (1).  Most  PTCLs  lack  distinct  genetic  or  biologic  alterations  that  are  seen  in  B-cell  lymphomas,  such  as  t(14;18)  in  follicular  lymphoma  and  t(11;14)  in  mantle  cell  lymphoma.  Compared  with  B-cell  lymphomas,  many  types  of  PTCL  develop  not  in  lymph  nodes,  but  in  specific  extranodal  sites  such  as  extranodal  NK/T-cell  lymphoma,  nasal  type  (ENKL)  in  the  nasal  cavity,  enteropathy-associated  T-cell  lymphoma  (EATL)  in  the  small  intestine,  and  hepatosplenic  T-cell  lymphoma  (HSTL)  in  the  liver  and  spleen.