RT Book, Section
A1 Hilal-Dandan, Randa
A1 Brunton, Laurence L.
SR Print(0)
ID 1127555064
T1 Natural Products in Cancer Chemotherapy: Hormones and Related Agents
T2 Goodman and Gilman's Manual of Pharmacology and Therapeutics, 2e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071769174
LK hemonc.mhmedical.com/content.aspx?aid=1127555064
RD 2024/04/20
AB The  growth  of  a  number  of  cancers  is  hormone-dependent  or  regulated  by  hormones.  Glucocorticoids  are  used  for  their  antiproliferative  and  lympholytic  properties  and  to  ameliorate  untoward  responses  to  other  treatments.  Estrogen,  androgen,  and  GnRH  analogs  and  antagonists  are  effective  in  extending  survival  and  delaying  or  preventing  tumor  recurrence  of  both  breast  and  prostate  cancer.  These  molecules  interrupt  the  stimulatory  axis  created  by  systemic  pools  of  androgens  and  estrogens,  inhibit  hormone  production  or  hormone  binding  to  receptors,  and  ultimately  block  expression  of  genes  that  promote  tumor  growth  and  survival.