RT Book, Section
A1 Chabner, Bruce A.
A2 Chabner, Bruce A.
A2 Longo, Dan L.
SR Print(0)
ID 1127646271
T1 Antimetabolites: Nucleoside and Base Analogs
T2 Harrison's Manual of Oncology, 2e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071793254
LK hemonc.mhmedical.com/content.aspx?aid=1127646271
RD 2024/04/19
AB The  synthesis  of  new  DNA  is  an  essential  step  in  the  replication  of  normal  and  malignant  cells.  Accordingly,  the  four  bases  that  comprise  DNA  (the  pyrimidines:  cytosine,  thymine;  and  the  purines:  adenine,  and  guanine)  have  provided  a  rational  target  for  synthesis  of  analogues  that  inhibit  the  function  of  DNA,  including  its  replication.  These  bases  become  active  substrates  for  DNA  synthesis  through  the  attachment  of  deoxyribose  sugars  to  form  a  deoxynucleoside.  Three  phosphate  molecules  must  then  be  attached  to  the  5′-OH  position  of  the  nucleoside's  sugar,  forming  a  metabolically  active  deoxynucleotide.  These  synthetic  reactions,  which  lead  to  formation  of  the  triphosphates  required  for  making  DNA,  occur  within  the  cancer  cell,  as  well  as  within  normal  proliferating  tissues,  such  as  bone  marrow  and  epithelium.