RT Book, Section
A1 Amrein, Philip C.
A2 Chabner, Bruce A.
A2 Longo, Dan L.
SR Print(0)
ID 1127647973
T1 Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
T2 Harrison's Manual of Oncology, 2e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071793254
LK hemonc.mhmedical.com/content.aspx?aid=1127647973
RD 2024/04/23
AB Chronic  lymphocytic  leukemia  (CLL)  is  a  neoplastic  disease  characterized  by  the  accumulation  of  monoclonal  lymphocytes  in  blood,  bone  marrow,  and  lymphoid  tissues.  These  lymphocytes  are  small,  mature-appearing  B  cells  typically  expressing  CD19,  CD5,  and  CD23.  It  is  generally  a  disease  of  older  people  and  prognosis  ranges  widely  from  a  few  years  to  many  years,  but  it  is  not  considered  curable  outside  of  the  bone  marrow  transplant  setting.  At  times  these  neoplastic  cells  predominate  in  lymph  nodes  leading  to  the  classification  as  a  lymphoma.  Hence,  the  WHO  in  2008  has  defined  this  neoplasm  as  chronic  lymphocytic  leukemia/small  lymphocytic  lymphoma  (CLL/SLL)  (1).