RT Book, Section
A1 Eichler, April F.
A2 Chabner, Bruce A.
A2 Longo, Dan L.
SR Print(0)
ID 1127649918
T1 Metastatic Brain Tumors
T2 Harrison's Manual of Oncology, 2e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071793254
LK hemonc.mhmedical.com/content.aspx?aid=1127649918
RD 2024/04/19
AB Brain  metastasis  is  a  common  complication  of  cancer.  Recent  population-based  data  suggest  that  up  to  20%  of  adults  with  cancer  will  develop  symptomatic  brain  metastases  during  life  (1).  Autopsy  studies  indicate  that  another  25%–30%  of  patients  with  disseminated  cancer  have  asymptomatic  brain  metastases  at  the  time  of  death.  The  incidence  of  brain  metastasis  varies  by  primary  cancer  type,  being  highest  for  lung  (20%)  followed  by  melanoma  (7%),  renal  (6.5%),  breast  (5%),  and  colorectal  (1.8%).  Prostate,  gynecologic,  head  and  neck,  and  non-melanomatous  skin  cancers  involve  the  brain  parenchyma  infrequently.  The  prevalence  of  brain  metastases  has  increased  in  the  past  three  decades.  Contributing  factors  may  include  more  sensitive  imaging  techniques  (gadolinium  enhanced  MRI),  lengthened  survival  due  to  more  effective  systemic  therapies,  and  poor  central  nervous  system  (CNS)  penetration  of  many  chemotherapeutic  and  antibody-based  agents.