RT Book, Section
A1 Hillman, Robert S.
A1 Ault, Kenneth A.
A1 Leporrier, Michel
A1 Rinder, Henry M.
SR Print(0)
ID 1127767990
T1 MONOCYTE-MACROPHAGE DISORDERS
T2 Hematology in Clinical Practice, 5e
YR 2016
FD 2016
PB McGraw-Hill Medical
PP New York, NY
SN 9780071626996
LK hemonc.mhmedical.com/content.aspx?aid=1127767990
RD 2024/04/23
AB CASE  HISTORY  •  Part  1A  45-year-old  man  is  referred  by  his  orthopedic  surgeon  following  the  development  of  a  pathological  fracture  of  the  neck  of  the  femur  after  a  fall  on  ice.  X-rays  taken  at  the  time  of  the  fracture  show  an  abnormality  of  the  ends  of  the  long  bones  resembling  an  inverted  Erlenmeyer  flask.The  patient  has  otherwise  been  in  good  health.  He  is  of  Ashkenazi  Jewish  descent  with  a  small  family  and  is  unaware  of  any  genetic  disorders  in  his  family.Examination  is  notable  for  an  enlarged  spleen,  which  is  easily  palpable  several  centimeters  below  the  costal  margin,  and  hepatomegaly.  The  remainder  of  his  physical  examination  is  normal.His  complete  blood  count  (CBC)  is  normal  with  the  exception  of  a  moderately  reduced  platelet  count  of  80,000/μL.QuestionsGiven  this  limited  amount  of  information,  what  diagnoses  come  to  mind?What  additional  tests  and  procedures  are  necessary  to  evaluate  this  patient?