RT Book, Section
A1 Hillman, Robert S.
A1 Ault, Kenneth A.
A1 Leporrier, Michel
A1 Rinder, Henry M.
SR Print(0)
ID 1127768032
T1 NORMAL HEMOSTASIS
T2 Hematology in Clinical Practice, 5e
YR 2016
FD 2016
PB McGraw-Hill Medical
PP New York, NY
SN 9780071626996
LK hemonc.mhmedical.com/content.aspx?aid=1127768032
RD 2024/04/24
AB Normal  hemostasis  is  best  conceptualized  according  to  its  major  components—vessel  wall,  platelet  function,  coagulation  factor  cascade,  and  clot  inhibition/fibrinolysis.  These  components  work  together  to  prevent  prolonged  bleeding  or  thrombosis  under  normal  physiologic  conditions.  Disruption  of  the  vascular  endothelium  is  a  potent  stimulus  to  clot  formation.  As  a  localized  process,  hemostasis  by  cellular  and  protein  components  acts  to  seal  the  break  in  vascular  continuity,  limit  blood  loss,  and  begin  the  process  of  wound  healing.  Prevention  of  an  exuberant  response  that  would  result  in  pathologic  thrombosis  involves  counterbalancing  mechanisms,  including  anticoagulant  properties  of  intact  endothelial  cells,  circulating  inhibitors  of  activated  coagulation  factors,  and  localized  fibrinolytic  enzymes.  Most  abnormalities  in  hemostasis  involve  a  defect  in  1  or  more  of  the  integrated  steps  in  this  coagulation  process.  It  is  important,  therefore,  to  understand  the  physiology  of  hemostasis.