RT Book, Section
A1 Young, Neal S.
A2 Longo, Dan L.
SR Print(0)
ID 1128353667
T1 APLASTIC ANEMIA, MYELODYSPLASIA, AND RELATED BONE MARROW FAILURE SYNDROMES
T2 Harrison's Hematology and Oncology, 2e
YR 2013
FD 2013
PB McGraw-Hill Education
PP New York, NY
SN 9780071814904
LK hemonc.mhmedical.com/content.aspx?aid=1128353667
RD 2024/04/19
AB The  hypoproliferative  anemias  are  normochromic,  normocytic,  or  macrocytic  and  are  characterized  by  a  low  reticulocyte  count.  Deficient  production  of  red  blood  cells  (RBCs)  occurs  with  marrow  damage  and  dysfunction,  which  may  be  secondary  to  infection,  inflammation,  and  cancer.  Hypoproliferative  anemia  is  also  a  prominent  feature  of  hematologic  diseases  that  are  described  as  bone  marrow  failure  states;  these  include  aplastic  anemia,  myelodysplastic  syndrome  (MDS),  pure  RBC  aplasia  (PRCA),  and  myelophthisis.  Anemia  in  these  disorders  is  often  not  a  solitary  or  even  the  major  hematologic  finding.  More  frequent  in  bone  marrow  failure  is  pancytopenia:  anemia,  leukopenia,  and  thrombocytopenia.  Low  blood  counts  in  the  marrow  failure  diseases  result  from  deficient  hematopoiesis,  as  distinguished  from  blood  count  depression  due  to  peripheral  destruction  of  RBCs  (hemolytic  anemias),  platelets  (idiopathic  thrombocytopenic  purpura  [ITP]  or  due  to  splenomegaly),  and  granulocytes  (as  in  the  immune  leukopenias).