RT Book, Section
A1 Dalmau, Josep
A1 Rosenfeld, Myrna R.
A2 Longo, Dan L.
SR Print(0)
ID 1128358412
T1 PARANEOPLASTIC NEUROLOGIC SYNDROMES
T2 Harrison's Hematology and Oncology, 2e
YR 2013
FD 2013
PB McGraw-Hill Education
PP New York, NY
SN 9780071814904
LK hemonc.mhmedical.com/content.aspx?aid=1128358412
RD 2024/04/24
AB Paraneoplastic  neurologic  disorders  (PNDs)  are  cancer-related  syndromes  that  can  affect  any  part  of  the  nervous  system  (Table  53-1).  They  are  caused  by  mechanisms  other  than  metastasis  or  by  any  of  the  complications  of  cancer  such  as  coagulopathy,  stroke,  metabolic  and  nutritional  conditions,  infections,  and  side  effects  of  cancer  therapy.  In  60%  of  patients,  the  neurologic  symptoms  precede  the  cancer  diagnosis.  Clinically  disabling  PNDs  occur  in  0.5–1%  of  all  cancer  patients,  but  they  affect  2–3%  of  patients  with  neuroblastoma  or  small  cell  lung  cancer  (SCLC)  and  30–50%  of  patients  with  thymoma  or  sclerotic  myeloma.