RT Book, Section
A1 Lichtman, Marshall A.
A1 Kaushansky, Kenneth
A1 Prchal, Josef T.
A1 Levi, Marcel M.
A1 Burns, Linda J.
A1 Armitage, James O.
SR Print(0)
ID 1133363834
T1 Pharmacology and Toxicity of Antineoplastic Drugs
T2 Williams Manual of Hematology, 9e
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9781259642470
LK hemonc.mhmedical.com/content.aspx?aid=1133363834
RD 2024/04/19
AB Knowledge  of  drug  actions,  clinical  toxicities,  pharmacokinetics,  and  drug  interactions  is  essential  for  the  safe  and  effective  administration  of  cancer  chemotherapy.Base  treatment  on  evidence  from  clinical  trials.Use  established  regimens  and  recheck  doses.Choice  of  a  particular  drug  treatment  program  should  depend  on  the  disease,  histology,  and  stage  of  the  disease  and  on  an  assessment  of  individual  patient  tolerance.High-dose  chemotherapy  programs  used  in  autologous  and  allogeneic  hematopoietic  cell  transplantation  result  in  additional  organ  toxicities  that  are  not  seen  at  conventional  doses.Chemotherapy  often  targets  process  of  DNA  replication.More  recently,  drugs  have  been  introduced  to  target  specific  cellular  processes,  including  receptor  signaling,  inhibition  of  oncoproteins,  angiogenesis,  and  membrane  cluster  of  differentiation  antigens.