RT Book, Section
A1 Lichtman, Marshall A.
A1 Kaushansky, Kenneth
A1 Prchal, Josef T.
A1 Levi, Marcel M.
A1 Burns, Linda J.
A1 Armitage, James O.
SR Print(0)
ID 1133364284
T1 Primary Myelofibrosis
T2 Williams Manual of Hematology, 9e
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9781259642470
LK hemonc.mhmedical.com/content.aspx?aid=1133364284
RD 2024/04/20
AB Primary  myelofibrosis  is  a  chronic  myeloid  neoplasm  that  originates  in  mutations  in  a  multipotential  hematopoietic  cell,  possibly  the  lymphohematopoietic  stem  cell.  The  disease  is  characterized  by  (1)  anemia;  (2)  splenomegaly;  (3)  increased  CD34+  cells,  immature  granulocytes,  erythroid  precursors,  and  teardrop-shaped  red  cells  in  the  blood;  (4)  increased  dysmorphic  megakaryocytes,  the  cytokines  from  which  induce  marrow  fibrosis;  and  (5)  osteosclerosis.