RT Book, Section
A1 Lee, Wayne S.
A1 Shen, Wen T.
A1 Duh, Quan-Yang
A2 Morita, Shane Y.
A2 Balch, Charles M.
A2 Klimberg, V. Suzanne
A2 Pawlik, Timothy M.
A2 Posner, Mitchell C.
A2 Tanabe, Kenneth K.
SR Print(0)
ID 1145758050
T1 Adrenocortical Cancer
T2 Textbook of Complex General Surgical Oncology
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9780071793315
LK hemonc.mhmedical.com/content.aspx?aid=1145758050
RD 2024/04/20
AB Adrenocortical  carcinoma  (ACC)  is  a  rare  but  often  aggressive  endocrine  malignancy  that  may  present  with  symptoms  of  hormone  secretion,  as  a  symptomatic  nonfunctional  abdominal  mass,  or  as  an  incidental  imaging  finding.  The  first  known  successful  adrenal  cancer  resection  was  performed  by  Knowsley  Thornton  in  1890.1,2  In  the  same  year,  Otto  Ramsay  published  a  small  case  series  of  patients  with  malignant  adrenal  tumors.3  However,  prognosis  was  poor  as  tumor  excision  offered  only  temporarily  relief  with  the  majority  of  patients  suffering  from  severe  adrenal  insufficiency.  In  1949,  discovery  of  cortisone,  derived  from  an  adrenocortical  extract  developed  by  the  Mayo  group,  significantly  improved  survival  from  adrenalectomy.4  Other  milestones  include  the  introduction  of  mitotane,  a  pesticide  derivative,  which  was  first  used  in  1960  to  treat  inoperable  or  recurrent  ACC.5