RT Book, Section
A1 Cohn, David E.
A1 Alvarez, Ronald D.
A2 Karlan, Beth Y.
A2 Bristow, Robert E.
A2 Li, Andrew J.
SR Print(0)
ID 1106570860
T1 High-Grade Serous Carcinomas of the Ovary, Fallopian Tube, and Peritoneum
T2 Gynecologic Oncology: Clinical Practice and Surgical Atlas
YR 2015
FD 2015
PB McGraw-Hill Medical
PP New York, NY
SN 9780071749268
LK hemonc.mhmedical.com/content.aspx?aid=1106570860
RD 2024/04/19
AB Epithelial  ovarian,  fallopian  tube,  and  primary  peritoneal  cancers  remain  the  most  lethal  of  all  the  gynecologic  malignancies.  In  2010,  approximately  21,880  women  will  be  diagnosed  with  ovarian  cancer  in  the  United  States;  of  these,  13,850  will  be  expected  to  die  from  this  disease.1  Cancers  arising  from  the  fallopian  tube  and  peritoneum  are  significantly  less  common  that  those  arising  from  the  ovarian  epithelium,  but  share  several  similarities  in  their  epidemiology,  diagnosis,  treatment,  and  associated  outcomes.  Because  the  vast  majority  of  fallopian  tube  and  primary  peritoneal  cancers  exhibit  a  high-grade  papillary  serous  histology,  comparisons  to  similar  disease  in  primary  ovarian  cancers  suggest  common  molecular  pathways  that  may  promote  carcinogenesis  within  the  serous  classification  of  these  tumors.  Several  recent  hypotheses  also  propose  a  fallopian  tube  origin  for  metastatic  disease  that  would  traditionally  be  considered  as  primary  ovarian  or  peritoneal.  Given  the  recent  advances  surrounding  these  diseases,  this  chapter  considers  this  subset  of  high-grade  serous  reproductive  cancers  as  a  group,  with  specific  differences  highlighted.