RT Book, Section
A1 Sfakianos, Gregory P.
A1 Secord, Angeles Alvarez
A1 Shih, Ie-Ming
A2 Karlan, Beth Y.
A2 Bristow, Robert E.
A2 Li, Andrew J.
SR Print(0)
ID 1106570956
T1 Epithelial Ovarian Cancers: Low Malignant Potential and Non-Serous Ovarian Histologies
T2 Gynecologic Oncology: Clinical Practice and Surgical Atlas
YR 2015
FD 2015
PB McGraw-Hill Medical
PP New York, NY
SN 9780071749268
LK hemonc.mhmedical.com/content.aspx?aid=1106570956
RD 2024/04/20
AB Epithelial  ovarian  cancer  is  the  leading  cause  of  death  from  gynecologic  cancers  and  the  fifth  leading  cause  of  all  cancer-related  deaths  among  women.  The  American  Cancer  Society  estimates  that  21,880  new  cases  of  ovarian  cancer  will  be  diagnosed  and  13,850  women  will  die  of  the  disease  in  the  United  States  in  2010.1  Approximately  90%  of  epithelial  ovarian  cancers  are  derived  from  coelomic  epithelium  of  the  ovary,  fallopian  tube,  or  peritoneum.  Epithelial  ovarian  cancers  are  heterogeneous  and  comprise  a  group  of  neoplasms  that  differ  based  on  their  histopathologic  and  molecular  features,  as  well  as  their  clinical  behavior.2,3  These  include  low  malignancy  potential  (LMP)  tumors  and  frankly  invasive  malignant  neoplasms.  Malignant  ovarian  cancers  can  be  further  subdivided  into  2  distinct  groups  based  on  their  morphologic  and  molecular  genetics  features.  Type  I  tumors  include  low-grade  serous,  mucinous,  low-grade  endometrioid,  clear  cell,  and  transitional  (Brenner)  carcinomas.  Conversely,  type  II  tumors  include  high-grade  serous  carcinoma,  high-grade  endometrioid  carcinoma,  malignant  mixed  mesodermal  tumors  (carcinosarcomas),  and  undifferentiated  carcinomas.4  Type  II  tumors  are  characterized  as  highly  aggressive,  evolving  rapidly,  and  uniformly  having  poor  outcomes.  In  contrast,  LMP  and  type  I  tumors  tend  to  be  diagnosed  at  an  earlier  stage,  behave  in  an  indolent  fashion,  and  have  a  better  prognosis.