RT Book, Section
A1 Reddy, Vishnu VB
A1 Prchal, Josef T.
A2 Kaushansky, Kenneth
A2 Lichtman, Marshall A.
A2 Prchal, Josef T.
A2 Levi, Marcel M.
A2 Press, Oliver W.
A2 Burns, Linda J.
A2 Caligiuri, Michael
SR Print(0)
ID 1121092966
T1 Anemia Associated with Marrow Infiltration
T2 Williams Hematology, 9e
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071833004
LK hemonc.mhmedical.com/content.aspx?aid=1121092966
RD 2024/04/19
AB SUMMARYMyelophthisic  anemia  is  caused  by  marrow  infiltration,  typically  by  metastatic  cancer,  and  by  any  nonhematopoietic  conditions,  for  example,  granulomatous  inflammation  or  fibrosis.  It  can  present  with  an  overt  leukoerythroblastic  picture  or  with  only  a  few  teardrop-shaped  red  cells  on  a  blood  film.  These  changes  may  represent  an  early  spread  of  the  tumor  (or  other  nonhematopoietic  tissue)  to  the  marrow  or  may  indicate  massive  replacement  of  the  marrow  space.  The  diagnosis  can  be  made  by  standard  marrow  biopsy.  Radioisotope  scanning  and  magnetic  resonance  imaging,  although  not  very  sensitive,  can  be  helpful  in  locating  the  biopsy  site  and  can  also  help  in  estimating  the  percentage  of  involvement  of  the  marrow  space.