RT Book, Section
A1 Lichtman, Marshall A.
A2 Kaushansky, Kenneth
A2 Lichtman, Marshall A.
A2 Prchal, Josef T.
A2 Levi, Marcel M.
A2 Press, Oliver W.
A2 Burns, Linda J.
A2 Caligiuri, Michael
SR Print(0)
ID 1121094459
T1 Hemolytic Anemia Resulting from Infections with Microorganisms
T2 Williams Hematology, 9e
YR 2015
FD 2015
PB McGraw-Hill Education
PP New York, NY
SN 9780071833004
LK hemonc.mhmedical.com/content.aspx?aid=1121094459
RD 2024/04/19
AB SUMMARYHemolytic  anemia  is  a  prominent  part  of  the  clinical  presentation  of  patients  infected  with  organisms  such  as  the  Plasmodium  sp.,  Babesia,  and  Bartonella,  which  directly  invade  the  erythrocyte.  Malaria  is  the  most  common  cause  of  hemolytic  anemia  on  a  worldwide  basis,  and  much  has  been  learned  about  how  the  parasite  enters  the  erythrocyte  and  the  mechanism  of  anemia.  Falciparum  malaria,  in  particular,  can  cause  severe  and  sometimes  fatal  hemolysis  (blackwater  fever).  Other  organisms  cause  hemolytic  anemia  by  producing  a  hemolysin  (e.g.,  Clostridium  perfringens),  by  stimulating  an  immune  response  (e.g.,  Mycoplasma  pneumoniae),  by  enhancing  macrophage  recognition  and  hemophagocytosis,  or  by  as  yet  unknown  mechanisms.  The  many  different  infections  that  have  been  associated  with  hemolytic  anemia  are  tabulated  and  references  to  the  original  studies  provided.