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Incidence: 12,360 (Estimated new cases for 2014 in the United States) Stage at Presentation
Localized: 55%
7.9 per 100,000 women per year Regional: 32%
Deaths: Estimated 4020 in 2014 Distant: 8%
Median age: 49 years Unstaged: 6%

Siegel R et al. CA Cancer J Clin 2013;63:11–30

Surveillance, Epidemiology and End Results (SEER) Program. Available from: <>; Accessed 2013


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Stage IA/Stage IB1:
  • H&P

  • CBC with platelet count, LFTs, BUN, creatinine

  • Cervical biopsy (pathologic review)

  • Cone biopsy as indicated

  • Chest x-ray, intravenous pyelogram, for IB1 CT/MRI ± PET ± lymphangiogram

Stage IB2 or greater:
  • Chest x-ray, intravenous pyelogram, or CT/MRI ± PET ± lymphangiogram

  • Consider examination under anesthesia

Stages III/IV:
  • Consider cystoscopy/proctoscopy


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Squamous cell carcinomas

  • Large cell, keratinizing

  • Large cell, nonkeratinizing

  • Small cell (not neuroendocrine)

  • Verrucous carcinoma



  • Adenoma malignum

  • Mucinous

  • Papillary

  • Endometrioid

  • Clear cell

  • Adenoid cystic

Adenosquamous 6%
Glassy cell carcinoma Rare
Neuroendocrine small cell carcinoma Rare

Galic V et al. Gynecol Oncol. 2012;125:287–291

Hunter RD. In: Souhami RL, Tannock I, Hohenberger P, Horiot J-C, eds. Oxford Textbook of Oncology, 2nd ed. New York: Oxford University Press; 2002:1835–1837

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Histologic Grade

Gx Cannot be assessed
G1 Well differentiated
G2 Moderately differentiated
G3 Poorly differentiated
G4 Undifferentiated


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Primary Tumor (T)
TNM Category FIGO Stage  
TX   Primary tumor cannot be assessed
T0   No evidence of primary tumor
Tis Carcinoma in situ (preinvasive carcinoma)
T1 I Cervical carcinoma confined to uterus (extension to corpus should be disregarded)
T1a IA Invasive carcinoma diagnosed only by microscopy. Stromal invasion with a maximum depth of 5.0 mm measured from the base of the epithelium and a horizontal spread of 7.0 mm or less. Vascular space involvement, venous or lymphatic, does not affect classification
T1a1 IA1 Measured stromal invasion 3.0 mm or less in depth and 7.0 mm or less in horizontal spread
T1a2 IA2 Measured stromal invasion more than 3.0 mm and not more than 5.0 mm with a horizontal spread 7.0 mm or less
T1b IB Clinically visible lesion confined to the cervix or microscopic lesion greater than T1a/IA2
T1b1 IB1 Clinically visible lesion 4.0 cm or less in greatest dimension
T1b2 IB2 Clinically visible lesion more than 4.0 cm in greatest dimension
T2 II Cervical carcinoma invades beyond uterus but not to pelvic wall or to lower third of vagina
T2a IIA Tumor without parametrial invasion
T2a1 IIA1 Clinically visible lesion 4.0 cm or less in greatest dimension
T2a2 IIA2 Clinically visible lesion more than 4.0 cm in greatest dimension
T2b IIB Tumor with parametrial invasion
T3 III Tumor extends to pelvic wall and/or involves ...

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