++
++
Pathology (WHO 2008)
AIDS-related lymphoma
Primary cutaneous CD30 positive T-cell lymphoproliferative disorders
Cutaneous B-cell lymphoma
Primary marginal zone
Follicular center
Primary cutaneous diffuse large B-cell lymphoma of leg
Primary cutaneous diffuse large B-cell lymphoma, other
2008 WHO Classification of Lymphomas
Precursor Lymphoid Neoplasms
B lymphoblastic leukemia/lymphoma NOS
B lymphoblastic leukemia/lymphoma with recurrent genetic abnormalities
B lymphoblastic leukemia/lymphoma with t(9;22); bcr-abl1
B lymphoblastic leukemia/lymphoma with t(v;11q23); MLL rearranged
B lymphoblastic leukemia/lymphoma with t(12:21); TEL-AML1 and ETV6-RUNX1
B lymphoblastic leukemia/lymphoma with hyperploidy
B lymphoblastic leukemia/lymphoma with hypodiploidy
B lymphoblastic leukemia/lymphoma with t(5;14); IL3-IGH
B lymphoblastic leukemia/lymphoma with t(1;19); E2A-PBX1 and TCF3-PBX1
T lymphoblastic leukemia/lymphoma
Mature B-Cell Neoplasms
Chronic lymphocytic leukemia/small lymphocytic lymphoma
B-cell prolymphocytic leukemia
Splenic marginal zone lymphoma
Hairy cell leukemia
Lymphoplasmacytic lymphoma/Waldenström's macroglobulinemia
Heavy-chain disease
Plasma cell myeloma
Solitary plasmacytoma of bone
Extraosseous plasmacytoma
Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type
Nodal marginal zone lymphoma
Follicular lymphoma
Primary cutaneous follicular lymphoma
Mantle cell lymphoma
Diffuse large B-cell lymphoma, NOS
T-cell/histiocyte-rich large B-cell lymphoma
EBV+ DLBCL of the elderly
Diffuse large B-cell lymphoma associated with chronic inflammation
Lymphomatoid granulomatosis
Primary CNS type
Primary leg skin type
Primary mediastinal large B-cell lymphoma
Intravascular large B-cell lymphoma
ALK+ large B-cell lymphoma
Plasmablastic lymphoma
Large B-cell lymphoma associated with HHV8+ Castleman disease
Primary effusion lymphoma
Burkitt lymphoma
B-cell lymphoma, unclassifiable, Burkitt-like
B-cell lymphoma, unclassifiable, Hodgkin lymphoma-like
Mature T-Cell and NK-Cell Neoplasms
T-cell prolymphocytic leukemia
T-cell large granular lymphocytic leukemia
Chronic lymphoproliferative disorder of NK-cells
Aggressive NK-cell leukemia
Systemic EBV+ T-cell lymphoproliferative disorder of childhood
Hydroa vacciniforme-like lymphoma
Adult T-cell lymphoma/leukemia
Extranodal T-cell/NK-cell lymphoma, nasal type
Enteropathy-associated T-cell lymphoma
Hepatosplenic T-cell lymphoma
Subcutaneous panniculitis-like T-cell lymphoma
Mycosis fungoides
Sézary syndrome
Primary cutaneous CD30+ T-cell lymphoproliferative disorder
Primary cutaneous gamma-delta T-cell lymphoma
Peripheral T-cell lymphoma, NOS
Angioimmunoblastic T-cell lymphoma
Anaplastic large cell lymphoma, ALK+ type
Anaplastic large cell lymphoma, ALK− type
Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW, eds. World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues. Lyon, France: IARC Press, 2008
++
Work-up
Immunophenotyping
Cytogenetics for CLL/SLL and Burkitt lymphoma
PET scan
Aggressive histology
PET scan recommended before and after treatment, mid cycle only appropriate in clinical trial setting
Also indicated for relapsed indolent disease when suspect aggressive transformation
Seam P et al. Blood ...