Sections View Full Chapter Figures Tables Videos Annotate Full Chapter Figures Tables Videos Supplementary Content +++ II.C.001 Alder-Reilly Anomaly ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) II.C.001 Alder-Reilly Anomaly. Blood film. Neutrophil with dense granules simulating toxic granulation. This abnormality of granular content in neutrophils is seen in the mucopolysaccharidoses. +++ II.C.002 Alder-Reilly Anomaly ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) II.C.002 Alder-Reilly Anomaly. Blood film. Neutrophil with dense granules simulating toxic granulation. This abnormality of granular content in neutrophils is seen in the mucopolysaccharidoses. +++ II.C.003 Chediak-Higashi disease ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) II.C.003 Chediak-Higashi disease. Blood film. Giant granule in neutrophil (arrow). Such neutrophilic granules are key diagnostic characteristics of the disease. Note also, larger than normal granules in the three other leukocytes in the field. +++ II.C.004 Chediak-Higashi disease ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) II.C.004 Chediak-Higashi disease. Blood film. Giant granules in neutrophil. These neutrophilic large granules are a diagnostic characteristic of the disease. +++ II.C.005 Chediak-Higashi Disease ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) II.C.005 Chediak-Higashi Disease. Blood film showing variable sized abnormal granules in the cytoplasm of neutrophils. Note varying sized abnormal granules from giant-sized to large granules. These abnormal granules are characteristic morphologic findings in cells in this autosomal recessive disorder. +++ II.C.006 Colchicine Poisoning ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) II.C.006 Colchicine Poisoning. Blood film. Abnormal neutrophil nuclear configurations. Decreased segmentation. +++ II.C.007 Döhle Bodies ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) II.C.007 Döhle bodies. Blood film. Large bluish granules in the cytoplasm of neutrophils as a reflection of inflammatory state. These inclusions are thought to represent basophilic material carried over from the promyelocyte stage, normally degraded, as a result of accelerated maturation of neutrophil precursors during inflammatory states +++ II.C.008 Hurler Disease ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) II.C.008 Hurler disease. Neutrophil. Blood film. Note numerous cytoplasmic granules characteristic of this mucopolysaccharidosis. Presumably these are lysosomal accumulations of glycosaminoglycans, characteristic of a deficiency in enzymes that degrade glycosaminoglycan (α-L-iduronidase in Hurler disease). +++ II.C.009 Hurler Disease ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) II.C.009 Hurler disease. Neutrophil. Blood film. Note numerous cytoplasmic granules characteristic of this mucopolysaccharidosis. Presumably these are lysosomal accumulations of glycosaminoglycans, characteristic of a deficiency in enzymes that degrade glycosaminoglycan (α-L-iduronidase in Hurler disease). +++ II.C.010 Leukocyte Adhesion Deficiency-1 ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) II.C.010 Leukocyte Adhesion Deficiency-1. Infant with Hemophilus sp. septicemia, Proteus sp. in urine culture, and viral otitis media. White cell count 55 ... Your Access profile is currently affiliated with '[InstitutionA]' and is in the process of switching affiliations to '[InstitutionB]'. Please click ‘Continue’ to continue the affiliation switch, otherwise click ‘Cancel’ to cancel signing in. Get Free Access Through Your Institution Learn how to see if your library subscribes to McGraw Hill Medical products. Subscribe: Institutional or Individual Sign In Username Error: Please enter User Name Password Error: Please enter Password Forgot Password? Forgot Username? Sign in via OpenAthens Sign in via Shibboleth