II.D: Eosinophils

II.D.001 Eosinophils, Normal

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II.D.001

Eosinophils, normal. Buffy coat (white cell concentrate). The field contains two eosinophils, two neutrophils, and a lymphocyte. The eosinophils are typical cells; bilobed nucleus, present in virtually all normal eosinophils, and a cytoplasm filled with eosinophilic granules. The granules do not obscure the nucleus as is characteristic in basophils. Some small areas without granules (degranulation) are present. Note that the neutrophil granules are too small to be resolved by the light microscope, whereas the large eosinophilic granules can be resolved. This is especially evident if eosinophilic granules are released from disrupted cells and are free in the surrounding area.

II.D.002 Eosinophil, Normal

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II.D.002

Eosinophil, normal. The field contains an eosinophil with characteristic bilobed nucleus, present in virtually all normal eosinophils, and a cytoplasm filled with eosinophilic granules. The granules do not obscure the nucleus as is characteristic in basophils. Some very small areas without granules (degranulation) are present—a common artifact of blood film preparation. Note severely hypochromic red cell as a result of iron deficiency.

II.D.003 Eosinophil, Normal

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II.D.003

II.D.004 Eosinophil, Hypersegmented

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II.D.004

Eosinophil, Hypersegmented. Blood film. The field contains an eosinophil with a trilobed nucleus, a reflection of the hypersegmentation of neutrophils and eosinophils seen in megaloblastic anemias resulting from vitamin B12 or folate deficiency. Some very small areas without granules (degranulation) are present a common artifact of blood film preparation. Normal eosinophils have a bilobed nucleus. Note the oval macrocytes, anisocytosis, and poikilocytosis of the red cells in megaloblastic anemia.

II.D.005 Eosinophil, Hypersegmented

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II.D.005

Eosinophil, hypersegmented. Blood film. The field contains an eosinophil with a five-lobed nucleus, a reflection of the hypersegmentation of neutrophils and eosinophils seen in megaloblastic anemia resulting from vitamin B12 or folate deficiency. Some very small areas without granules (degranulation) are present a common artifact of blood film preparation. Normal eosinophils have a bilobed nucleus. Note the oval macrocytes, anisocytosis, and poikilocytosis of the red cells in megaloblastic anemia.