Alder Reilly Anomaly. Blood film. Lymphocyte with large cytoplasmic granules characteristic of the mucopolysacchidoses.
Batten disease. (A-D) Lymphocytes displaying small and large vacuoles in cytoplasm. Batten disease is a fatal, inherited disorder of the nervous system that begins in childhood. In some cases, the early signs are subtle, taking the form of personality and behavior changes, slow learning, clumsiness, or stumbling. Symptoms of Batten disease result from accumulation of lipopigments made up of fats and proteins in the tissues.
Chediak-Higashi Disease. Blood Film. Large cytoplasmic granule observed in a blood lymphocyte, characteristic of this disorder.
Chediak-Higashi Disease. Blood Film. Two nuclei in lymphocyte. Unusual finding.
Congenital Rubella. Blood films. (A) Large plasmacytoid cell. Small nucleated red cell. (B) Two plasmacytoid cells with intensely blue cytoplasm.
Drug reaction. Blood film. Composite of reactive lymphocytes from patients undergoing drug reactions. (A) Large lymphocyte with nucleoli. (B) Large lymphocyte with nucleoli. (C) Lymphocyte with intensely blue cytoplasm (plasmacytoid lymphocyte).
Hurler disease. Blood film. Lymphocyte. Note numerous cytoplasmic granules characteristic of this mucopolysaccharidosis. Presumably these are lysosomal accumulations of glycosaminoglycans, characteristic of this deficiency in enzymes that degrade glycosaminoglycan (α-L-iduronidase in Hurler disease).
Infectious lymphocytosis. Blood film. Increased lymphocyte count with small lymphocytes as the characteristic cell.
Infectious mononucleosis. Blood film. Three large lymphocytes with abundant cytoplasm. Cytoplasmic periphery conforms to red cell outlines. Nuclear shape not a strict circle but elongated or irregular.
Infectious mononucleosis. Blood film. Four large lymphocytes with abundant cytoplasm. Cytoplasmic periphery conforms to red cell outlines. Nuclear shape not a strict circle but elongated or irregular.