Sections View Full Chapter Figures Tables Videos Annotate Full Chapter Figures Tables Videos Supplementary Content +++ IV.A.001 Bernard-Soulier Disease ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) IV.A.001 Bernard-Soulier disease. Blood film. Note large platelets. Some giant-sized platelets are the diameter of red cells with a range from slightly enlarged (one-third the diameter of a red cell) to enormous. +++ IV.A.002 Gray Platelet Syndrome (α-Granule Deficiency) ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) IV.A.002 Gray platelet syndrome (α-granule deficiency). Blood film. The platelets are characteristically larger than normal and are pale gray forms. Although thrombocytopenia may occur that is not the case in this example. +++ IV.A.003 Gray Platelet Syndrome (α-Granule Deficiency) ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) IV.A.003 Gray platelet syndrome (α-granule deficiency). Blood film. Periodic acid Schiff stain. The platelets are characteristically larger than normal. This agranular giant platelet stains for glycogen (pinkish-red) (arrow) as does normal neutrophil. +++ IV.A.004 Gray Platelet Syndrome: Transmission Electron Microscopy ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) IV.A.004 Gray platelet syndrome: Transmission electron microscopy. (A) Normal platelets. (B) Gray platelet syndrome. Note absence of α-granules, which imparts a bland gray appearance to platelets in the blood film. Occasional radio-opaque bodies are dense bodies. The platelets are rich in glycogen granules and are strongly periodic acid Schiff positive. +++ IV.A.005 May-Hegglin Anomaly ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) IV.A.005 May-Hegglin anomaly. A characteristic giant platelet. An abnormal neutrophil with classic gray-blue inclusions. Patients have a mutation of the MYH9 gene at chromosome region 22q12-13. The mutation results in disordered production of non-muscle myosin heavy-chain type IIA. This leads to macrothrombocytopenia, secondary to defective megakaryocyte maturation and fragmentation. Thrombocytopenia occurs in almost all patients, but severe bleeding is unusual. Individuals may bruise easily, and they may have recurrent epistaxis, gingival bleeding, menorrhagia, or excessive bleeding associated with surgical procedures. The neutrophil inclusions are precipitates of non-muscle myosin heavy-chain type IIA +++ IV.A.006 May-Hegglin Disease ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) IV.A.006 May-Hegglin disease. Blood film. Gray-blue giant neutrophil inclusion (arrow) and a giant platelet, the size of a red cell. Patients have a mutation of the MYH9 gene at chromosome region 22q12-13. The mutation results in disordered production of non-muscle myosin heavy-chain type IIA. This leads to macrothrombocytopenia, secondary to defective megakaryocyte maturation and fragmentation. Thrombocytopenia occurs in almost all patients, but severe bleeding is unusual. Individuals may bruise easily, and they may have recurrent epistaxis, gingival bleeding, menorrhagia, or excessive bleeding associated with surgical procedures. The neutrophil inclusions contain precipitates of non-muscle myosin heavy-chain type IIA. +++ IV.A.007 May-Hegglin Disease ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) IV.A.007 May-Hegglin disease. ... Your Access profile is currently affiliated with [InstitutionA] and is in the process of switching affiliations to [InstitutionB]. Please select how you would like to proceed. Keep the current affiliation with [InstitutionA] and continue with the Access profile sign in process Switch affiliation to [InstitutionB] and continue with the Access profile sign in process Get Free Access Through Your Institution Learn how to see if your library subscribes to McGraw Hill Medical products. Subscribe: Institutional or Individual Sign In Error: Incorrect UserName or Password Username Error: Please enter User Name Password Error: Please enter Password Sign in Forgot Password? Forgot Username? Sign in via OpenAthens Sign in via Shibboleth You already have access! Please proceed to your institution's subscription. Create a free profile for additional features.