Metastatic breast carcinoma. Marrow film. Cluster of breast carcinoma cells.
Breast Carcinoma. Metastatic breast carcinoma. Marrow biopsy. This marrow biopsy shows poorly differentiated metastatic breast carcinoma from a patient with a history of infiltrating lobular carcinoma. Superficially, these tumor cells resemble plasma cells.
Metastatic Breast Carcinoma Cells. (A) Marrow concentrate film. Note large cells with very large nuclei and heavily vacuolated cytoplasm. (B) Marrow biopsy. Cluster of large cells with very large nuclei and bold nucleoli. Vacuolated cytoplasm around the nuclear outlines.
Metastatic breast cancer, CD138 stain. Marrow biopsy. CD138 (syndecan-1) stain. Although more often associated with plasma cells, CD138 expression can also be expressed by carcinoma cells. The tumor cells shown also stained for cytokeratin. No detectable kappa or lambda light chain expression was present on in situ hybridization studies.
Metastatic breast cancer, cytokeratin stain. Cytokeratin immunohistochemistry stain on same marrow shown in Figure V.J.004 confirms that the tumor seen is metastatic carcinoma. Mixture of high and low molecular weight (AE-1/3 and Cam5.2) anticytokeratin antibodies was used, stained by standard peroxidase-antiperoxidase technique using 3-amino-9-ethylcarbazole substrate.
Ewing Sarcoma. Marrow film. Very Large Ewing sarcoma cells. Most with scant cytoplasm and one with evident large nucleolus.
Metastatic lung carcinoma cells. Marrow film. A cluster of metastatic lung cells.
Metastatic Lung Carcinoma Cells. Marrow Sections. (A, B) Aggregates of metastatic small cell carcinoma of the lung cells. Note large size compared to neutrophil in (B) and tendency to aggregate.
Metastatic prostatic carcinoma cells. Marrow film. A cluster of prostatic carcinoma cells.
Neuroblastoma cells. Marrow film. Note characteristic rosette formation of neuroblastoma cells.