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VII.C.001 Burkitt Lymphoma

VII.C.001

Burkitt lymphoma. Lymph node biopsy. Low power. H&E stain. Characteristic sheets of lymphoblasts with interspersed macrophages, the latter giving it a “starry sky” appearance.

VII.C.002 Burkitt Lymphoma

VII.C.002

Burkitt lymphoma. Lymph node biopsy. Ki-67 nuclear stain giving a red-brown color to the lymphoblasts and confirming high proliferative rate of >90% of cells. Ki-67 is cell cycle regulatory protein.

VII.C.003 Burkitt Lymphoma

VII.C.003

Burkitt lymphoma. Lymph node biopsy. Wright’s Giemsa stain of air-dried lymph node touch preparation shows blast-like large lymphoid cells with prominent nucleoli and frequent cytoplasmic vacuoles. Mitotic figures. Tissue equivalent of acute lymphoblastic leukemia of Burkitt type.

VII.C.004 Burkitt Lymphoma

VII.C.004

Burkitt lymphoma. Lymph node biopsy. Low power view. Note areas of clearing that impart the so-called “starry sky” appearance. These areas represent tingible-body macrophages within the tumor that are recruited to phagocytize cellular debris. A similar appearance may also be seen in other lymphomas that have a high proliferative rate.

VII.C.005 Burkitt Lymphoma

VII.C.005

Burkitt lymphoma. Lymph node. Biopsy. Higher power view. Individual tumor cells have a high nuclear: cytoplasmic ratio, round nuclear contours, and small, barely perceptible nucleoli (sometimes called “inconspicuous” nucleoli). These overall features are often referred to as a “small non-cleaved” cell or “small transformed” cell cytology.

VII.C.006 Burkitt Lymphoma

VII.C.006

Burkitt lymphoma. Lymph node biopsy. (A) Lower power view showing diffuse replacement of nodal tissue with Burkitt lymphoblasts with classical interspersed macrophages presenting a starry sky appearance. (B) Higher power view. Burkitt lymphoblasts with prominent nucleoli. Interspersed macrophages with ingested cellular debris. Relative increase in mitotic figures.

VII.C.007 Burkitt Lymphoma

VII.C.007

Burkitt lymphoma. Lymph node biopsy. (A) Lower power view showing diffuse replacement of nodal tissue with Burkitt lymphoblasts with classical interspersed macrophages presenting a starry sky appearance. (B) Higher power view. Burkitt lymphoblasts with prominent nucleoli. Interspersed macrophages with ingested cellular debris.

VII.C.008 Cryoglobulinemia

VII.C.008

Cryoglobulinemia. Blood films. (A) Gray precipitates in blood taken from a finger stick (acral cooling). Hypersegmented neutrophil. (B) Gray precipitates in blood taken from finger stick (acral cooling). Small platelet aggregate.

VII.C.009 Cryocrystalglobulinemia

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