Sections View Full Chapter Figures Tables Videos Annotate Full Chapter Figures Tables Videos Supplementary Content +++ VII.E.001 Hodgkin Lymphoma, Classical Type, Nodular Sclerosis Subtype ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) VII.E.001 Hodgkin lymphoma, classical type, nodular sclerosis subtype. Lymph node. H&E. Note large bands of collagen fibrosis (asterisk) dividing the tumor into macronodules of polymorphous lymphohistiocytic infiltrate. +++ VII.E.002 Hodgkin Lymphoma, Classical Type, Nodular Sclerosis Type ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) VII.E.002 Classical Hodgkin lymphoma, nodular sclerosis type. Photograph illustrates numerous Reed-Sternberg cells with retraction artifact induced by formalin fixation (lacunar cell variant of Hodgkin cells). +++ VII.E.003 Hodgkin Lymphoma ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) VII.E.003 Hodgkin lymphoma. Lymph node biopsy. H&E stain, intermediate magnification, showing mixed lymphohistiocytic infiltrate with scattered large cells (Reed-Sternberg and Reed-Sternberg variant cells). +++ VII.E.004 Hodgkin Lymphoma ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) VII.E.004 Hodgkin lymphoma. Lymph node biopsy. H&E stain, Reed-Sternberg cell. +++ VII.E.005 Hodgkin Lymphoma, CD30 Immunostain ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) VII.E.005 Hodgkin lymphoma. CD30 immunostain Lymph node biopsy, Reed-Sternberg cells. Positive reaction manifest by reddish-brown reaction in the Reed-Sternberg and Reed-Sternberg variant cells. Reed-Sternberg cells are binucleate giant cells with very large nucleoli. Variant cells are usually mononuclear with somewhat smaller nucleoli. +++ VII.E.006 Hodgkin Lymphoma, Classical Type, CD30 Immunostain ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) VII.E.006 Hodgkin lymphoma, classical type. Lymph node biopsy. CD30 immunostain. The reddish-brown reaction product highlights the characteristic Reed-Sternberg (RS) cells. +++ VII.E.007 Hodgkin Lymphoma, CD15 Immunostain ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) VII.E.007 Hodgkin lymphoma. CD15 immunostain. Lymph node biopsy. Immunostain produces reddish-brown reaction product in the Reed-Sternberg and Reed-Sternberg variant cells. +++ VII.E.008 Hodgkin Lymphoma, Classical Type, CD15 Immunostain ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) VII.E.008 Hodgkin lymphoma, classical type. CD15 immunostain. Lymph node biopsy. Immunostain produces reddish-brown reaction product in the Reed-Sternberg and Reed-Sternberg variant cells. +++ VII.E.009 Hodgkin Lymphoma, LCA Immunostain ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) VII.E.009 Hodgkin lymphoma. Leukocyte common antigen (LCA) immunostain. Lymph node biopsy. Immunostain shows that large Reed-Sternberg cells are LCA-negative, with surrounding LCA-positive lymphocytes (reddish-brown cytoplasmic staining). +++ VII.E.010 Hodgkin Lymphoma, Fascin Immunostain ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) VII.E.010 Hodgkin lymphoma. Fascin stain. Lymph node biopsy. Reed-Sternberg cells react with stain but not the surrounding small lymphocytes. +++ VII.E.011 Hodgkin Lympoma ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) VII.E.011 Hodgkin lymphoma. Lymph node biopsy. H&E. Lacunar variant ... Your Access profile is currently affiliated with [InstitutionA] and is in the process of switching affiliations to [InstitutionB]. Please select how you would like to proceed. Keep the current affiliation with [InstitutionA] and continue with the Access profile sign in process Switch affiliation to [InstitutionB] and continue with the Access profile sign in process Get Free Access Through Your Institution Learn how to see if your library subscribes to McGraw Hill Medical products. Subscribe: Institutional or Individual Sign In Error: Incorrect UserName or Password Username Error: Please enter User Name Password Error: Please enter Password Sign in Forgot Password? Forgot Username? Sign in via OpenAthens Sign in via Shibboleth You already have access! Please proceed to your institution's subscription. Create a free profile for additional features.