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VII.E.001 Hodgkin Lymphoma, Classical Type, Nodular Sclerosis Subtype

VII.E.001

Hodgkin lymphoma, classical type, nodular sclerosis subtype. Lymph node. H&E. Note large bands of collagen fibrosis (asterisk) dividing the tumor into macronodules of polymorphous lymphohistiocytic infiltrate.

VII.E.002 Hodgkin Lymphoma, Classical Type, Nodular Sclerosis Type

VII.E.002

Classical Hodgkin lymphoma, nodular sclerosis type. Photograph illustrates numerous Reed-Sternberg cells with retraction artifact induced by formalin fixation (lacunar cell variant of Hodgkin cells).

VII.E.003 Hodgkin Lymphoma

VII.E.003

Hodgkin lymphoma. Lymph node biopsy. H&E stain, intermediate magnification, showing mixed lymphohistiocytic infiltrate with scattered large cells (Reed-Sternberg and Reed-Sternberg variant cells).

VII.E.004 Hodgkin Lymphoma

VII.E.004

Hodgkin lymphoma. Lymph node biopsy. H&E stain, Reed-Sternberg cell.

VII.E.005 Hodgkin Lymphoma, CD30 Immunostain

VII.E.005

Hodgkin lymphoma. CD30 immunostain Lymph node biopsy, Reed-Sternberg cells. Positive reaction manifest by reddish-brown reaction in the Reed-Sternberg and Reed-Sternberg variant cells. Reed-Sternberg cells are binucleate giant cells with very large nucleoli. Variant cells are usually mononuclear with somewhat smaller nucleoli.

VII.E.006 Hodgkin Lymphoma, Classical Type, CD30 Immunostain

VII.E.006

Hodgkin lymphoma, classical type. Lymph node biopsy. CD30 immunostain. The reddish-brown reaction product highlights the characteristic Reed-Sternberg (RS) cells.

VII.E.007 Hodgkin Lymphoma, CD15 Immunostain

VII.E.007

Hodgkin lymphoma. CD15 immunostain. Lymph node biopsy. Immunostain produces reddish-brown reaction product in the Reed-Sternberg and Reed-Sternberg variant cells.

VII.E.008 Hodgkin Lymphoma, Classical Type, CD15 Immunostain

VII.E.008

Hodgkin lymphoma, classical type. CD15 immunostain. Lymph node biopsy. Immunostain produces reddish-brown reaction product in the Reed-Sternberg and Reed-Sternberg variant cells.

VII.E.009 Hodgkin Lymphoma, LCA Immunostain

VII.E.009

Hodgkin lymphoma. Leukocyte common antigen (LCA) immunostain. Lymph node biopsy. Immunostain shows that large Reed-Sternberg cells are LCA-negative, with surrounding LCA-positive lymphocytes (reddish-brown cytoplasmic staining).

VII.E.010 Hodgkin Lymphoma, Fascin Immunostain

VII.E.010

Hodgkin lymphoma. Fascin stain. Lymph node biopsy. Reed-Sternberg cells react with stain but not the surrounding small lymphocytes.

VII.E.011 Hodgkin Lympoma

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