Sections View Full Chapter Figures Tables Videos Annotate Full Chapter Figures Tables Videos Supplementary Content +++ VIII.C.001 T(9;22)(q34;q11.2). G-Banding ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) VIII.C.001 t(9;22)(q34;q11.2). Major rearrangement. G-banding. Classical form of the Ph chromosome translocation. Arrows point to the elongated derived chromosome 9 and shortened derived chromosome 22. The latter is the Philadelphia chromosome, now identified by the designation “Ph chromosome.” +++ VIII.C.002 T(9;22)(q34;q11.2). FISH ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) VIII.C.002 t(9;22)(q34;q11.2). Major rearrangement. FISH. Probe for 9q34 (ABL) (red) and 22q11.2 (BCR) (green). (A) Normal interphase cell. Two red and two green signals. (B) Abnormal cell. One fused signal indicates the derived chromosome 22 (the Ph-chromosome with the BCR and ABL genes fused). One red and green signal represents the normal chromosome 9 and 22. A smaller red signal represents the remaining part of chromosome 9 (derived 9). +++ VIII.C.003 T(9;22)(q34;q11.2) G-Banding ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) VIII.C.003 t(9;22)(q34;q11.2). Major rearrangement with the leftover ABL gene deleted on the derived chromosome 9. G-banding. The arrow indicates the foreshortened derived chromosome 22 (Ph chromosome) and the derived 9 with the leftover ABL gene deleted. (Compare to image VIII.C.1. The translocated piece of 22 is not apparent.). Major rearrangement with the leftover ABL gene deleted on the derived chromosome 9. G-banding. The arrow indicates the foreshortened derived chromosome 22 (Ph chromosome) and the derived 9 with the leftover ABL gene deleted. (Compare to image VIII.C.1. The translocated piece of 22 is not apparent.) +++ VIII.C.004 T(9;22)(q34;q11.2). FISH ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) VIII.C.004 t(9;22)(q34;q11.2). Major rearrangement with ABL leftover deleted. FISH. Probe for 9q34 (ABL gene) (red) and 22q11.2 (BCR gene) (green). (A) Normal interphase cell. Two chromosomes 9 (red signal) and two chromosomes 22 (green signal). (B) Abnormal cell. One red (normal chromosome 9) and green (normal chromosome 22) signal. One fused signal indicative of the derived chromosome 22 (Ph chromosome). Absence of a small red signal indicating the leftover ABL gene on the derived chromosome 9 is deleted (interphase preparation). (C) Abnormal cell. One red (normal chromosome 9) and green (normal chromosome 22) signal. One fused signal on the derived 22 indicative of Ph chromosome (metaphase preparation). +++ VIII.C.005 Duplication Ph Chromosome. G-Banding ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) VIII.C.005 Duplication Ph chromosome. G-banding. Arrows indicate two 22q deletions (double Ph chromosome but no apparent derived 9; translocated piece of 22 not apparent). (Compare to image VIII.C.1.) Note also trisomy 21. +++ VIII.C.006 Duplication Ph Chromosome. FISH ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) VIII.C.006 Duplication Ph chromosome. FISH. Probe for 9q34 (ABL gene) (red) and 22q11.2 (BCR gene) (green). (A) Normal interphase cell. Two chromosomes 9 (red signal) and two ... Your Access profile is currently affiliated with [InstitutionA] and is in the process of switching affiliations to [InstitutionB]. Please select how you would like to proceed. Keep the current affiliation with [InstitutionA] and continue with the Access profile sign in process Switch affiliation to [InstitutionB] and continue with the Access profile sign in process Get Free Access Through Your Institution Learn how to see if your library subscribes to McGraw Hill Medical products. Subscribe: Institutional or Individual Sign In Error: Incorrect UserName or Password Username Error: Please enter User Name Password Error: Please enter Password Sign in Forgot Password? Forgot Username? Download the Access App: iOS | Android Sign in via OpenAthens Sign in via Shibboleth You already have access! Please proceed to your institution's subscription. Create a free profile for additional features.