Sections View Full Chapter Figures Tables Videos Annotate Full Chapter Figures Tables Videos Supplementary Content +++ X.C.001 CD3, T Lymphocytes ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) X.C.001 CD3 immunostain of T lymphocytes. This reddish-brown reaction product identifies T lymphocytes. This image shows staining of a background of polyclonal reactive T lymphocytes amidst the centroblasts of large B cell lymphoma (e.g., asterisks). +++ X.C.002 CD10, Germinal Center B Lymphocytes ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) X.C.002 CD10 immunostain of germinal center B lymphocytes. This reddish-brown reaction product identifies, in this case, neoplastic follicular B cells, an immunophenotype that resembles normal germinal center cells. +++ X.C.003 CD15, Reed-Sternberg Cells ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) X.C.003 CD15 immunostain of Reed-Sternberg cells. The reddish-brown reaction product stains the cytoplasm of Reed-Sternberg cell (large binucleate cell in center of field) (arrow) and Reed-Sternberg variant cell (smaller mononuclear cells with reddish-brown reaction product in the cytoplasm) (asterisk) in a case of classical Hodgkin lymphoma. +++ X.C.004 CD20, B Lymphocytes ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) X.C.004 CD20 immunostain of B lymphocytes. The reddish-brown reaction product stains neoplastic lymphocytes with a B cell phenotype. Reactive T lymphocytes are unstained. +++ X.C.005 CD30, Red-Sternberg Cells ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) X.C.005 CD30 immunostain of Reed-Sternberg cells. This reddish-brown reaction product identifies Reed-Sternberg and Reed-Sternberg variant cells in Hodgkin lymphoma. Note classical binucleate Reed-Sternberg cell (e.g., arrow) and mononuclear variant Reed-Sternberg cells (e.g., asterisk). This immunostain also reacts with anaplastic large cell lymphoma and activated lymphocytes. +++ X.C.006 CD34 Stain. Acute myelogenous leukemia ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) X.C.006 CD34 stain for myeloblasts. Marrow biopsy. (A) Marrow shows replacement by monotonous population of blast cells. (B) Anti-CD34 staining of blast cells confirms the myeloblastic nature of the acute leukemia. +++ X.C.007 CD45RO, T. Lymphocytes ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) X.C.007 CD45R0 immunostain of T lymphocytes. This reddish-brown reaction product identifies the T cell origin of the tumor cells, as in this case of angioimmunoblastic T-cell lymphoma. +++ X.C.008 CD138 and Light Chain Immunostain. Myeloma ++ Graphic Jump LocationView Full Size||Download Slide (.ppt) X.C.008 A patient with myeloma undergoing chemotherapy. (A).Marrow biopsy stained with H & E. Occasional plasma cells noted.(B) Immunostain for CD138 (syndecan-1) shows numerous plasma cells. (C)Immunostain for lambda light chain indicates virtually all plasma cells expressing lambda light chains (D)Immunostain for kappa light chains. Only a rare positive plasma cells confirming substantial monoclonal plasma cell infiltrate (monoclonal lambda light chain type). +++ X.C.009 Cylin-D1, Mantle Cell Lymphoma ++ Graphic Jump LocationView Full Size||... Your Access profile is currently affiliated with [InstitutionA] and is in the process of switching affiliations to [InstitutionB]. Please select how you would like to proceed. Keep the current affiliation with [InstitutionA] and continue with the Access profile sign in process Switch affiliation to [InstitutionB] and continue with the Access profile sign in process Get Free Access Through Your Institution Learn how to see if your library subscribes to McGraw Hill Medical products. Subscribe: Institutional or Individual Sign In Error: Incorrect UserName or Password Username Error: Please enter User Name Password Error: Please enter Password Sign in Forgot Password? Forgot Username? Sign in via OpenAthens Sign in via Shibboleth You already have access! Please proceed to your institution's subscription. Create a free profile for additional features.