XI.A: External Manifestations

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XI.A.001

Acute hemorrhagic edema of infancy is an acute cutaneous leukocytoclastic vasculitis (LCV) of infants with a violent onset followed by spontaneous recovery. Edema and palpable purpuric skin lesions are present. Light microscopic examination of the skin biopsy specimens revealed LCV as in Henoch-Schönlein purpura. Acute hemorrhagic edema of infancy is observed before 2 years of age and is confined to the skin.

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XI.A.002

Amyloidosis, primary. Amyloid deposition in inferior and superior palpebrum. Note waxy surface.

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XI.A.003

Amyloidoses, primary. Amyloid deposition in tongue (macroglossia).

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XI.A.004

Antiphospholipid antibody syndrome. Anticardiolipin antibody. Ischemic skin changes resulting from thrombotic disease of superficial vessels.

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XI.A.005

Antiphospholipid antibody syndrome: lupus anticoagulant. Thrombosis of digital vessels with ischemic changes of the toes.

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XI.A.006

Aspergillosis: primary cutaneous lesion initiated from a contaminated arm-board. Primary cutaneous aspergillosis can occur in the absence of disseminated disease. In hospitalized patients, primary cutaneous aspergillosis lesions may arise around the sites of an intravenous catheter or a venipuncture site.

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XI.A.007

Disseminated candidiasis. Purpuric nodule and diffuse maculopapular and maculonodular rash in a patient with acute myelogenous leukemia with invasive (disseminated) candidiasis. The rash of candidiasis may be diffuse or only on the extremities. Biopsy, which includes the involved areas down to the dermis will show small oval blastospores with buds and pseudohyphae.

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XI.A.008

Chediak-Higashi disease. Five-year-old patient with thin fine hair, which is a dirty blonde with silver streaks, the result of misdistribution of giant melanophores in the hair follicle cells.

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XI.A.009

Chediak-Higashi disease. Normal and affected mink. The latter (on the right) has light gray hair and absence of pigment in the irises, which appear translucent. The affected child usually has similar findings. The pigment abnormality is the result of misdistribution of abnormal giant melanophores.